Temporal trends in age and stage-specific incidence of colorectal cancer in Saudi Arabia: A registry-based cohort study between 1997 and 2017

IF 2.4 3区医学 Q3 ONCOLOGY

Cancer Epidemiology Pub Date : 2024-11-13 DOI:10.1016/j.canep.2024.102699

Norah Alsadhan , Mar Pujades-Rodriguez , Sultana A. Alhurishi , Farag Shuweihdi , Cathy Brennan , Robert M. West

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引用次数: 0

Abstract

Background

In Saudi Arabia, colorectal cancer (CRC) is the most common cancer in men and the third in women, posing a significant health burden. A comprehensive report of CRC incidence rates and trends in Saudi Arabia is lacking. This study aims to examine trends in CRC incidence among the Saudi population.

Methods

We used data from the Saudi Cancer Registry to examine CRC age-specific incidence rates (ASIR) and age-standardized incidence rates (ASR) between 1997 and 2017. Joinpoint regression analysis was used to determine the magnitude and direction of observed trends stratified by age, sex, and CRC stage at diagnosis. Trends were measured using the annual percentage change (APC) and the average annual percentage change (AAPC) in CRC incidence rates.

Results

In total, 19,463 new CRC cases were identified during the study period. Since 1997, ASR for CRC has steadily increased in men and women overall, irrespective of disease stages. The ASIR increased across all age groups and was more pronounced in older patients. Women aged 40–49 had a higher increase in incidence than men (AAPC= 5.3 % vs.4.7 %). Males aged 70–79 had an AAPC of 10.2 %, twice that of females (AAPC= 4.9 %). A consistent rise in ASIR was observed across all CRC stages and age groups in males and females. In recent years, males under 50 had a higher APC for distant CRC than females, while females aged 50–74 experienced a steeper increase in distant CRC than males.

Conclusion

We report a marked increase in the incidence of CRC over time in Saudi Arabia, affecting men and women across all age groups and disease stages at diagnosis. Our findings underscore the need to identify underlying risk factors and to develop and implement effective prevention policies and strategies, including screening programs to facilitate early detection and treatment.

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沙特阿拉伯结直肠癌年龄和分期发病率的时间趋势：1997年至2017年间基于登记簿的队列研究。

背景：在沙特阿拉伯，结肠直肠癌（CRC）是男性最常见的癌症，是女性的第三大癌症，对健康造成了重大负担。沙特阿拉伯缺乏有关 CRC 发病率和趋势的全面报告。本研究旨在探讨沙特人口中 CRC 发病率的变化趋势：我们利用沙特癌症登记处的数据，研究了 1997 年至 2017 年间 CRC 年龄特异性发病率（ASIR）和年龄标准化发病率（ASR）。联结点回归分析用于确定按年龄、性别和确诊时的 CRC 分期分层的观察趋势的幅度和方向。使用 CRC 发病率的年度百分比变化（APC）和平均年度百分比变化（AAPC）来衡量趋势：研究期间共发现 19,463 例新的 CRC 病例。自 1997 年以来，无论疾病处于哪个阶段，男性和女性的 CRC 发病率总体上都在稳步上升。所有年龄组的ASIR都有所上升，老年患者的ASIR上升更为明显。40-49 岁女性的发病率增幅高于男性（AAPC= 5.3% 对 4.7%）。70-79 岁男性的 AAPC 为 10.2%，是女性的两倍（AAPC= 4.9%）。在所有儿童癌症阶段和年龄组中，男性和女性的 ASIR 均呈持续上升趋势。近年来，50 岁以下男性的远处 CRC APC 比女性高，而 50-74 岁女性的远处 CRC 比男性增加得更快：我们的报告显示，随着时间的推移，沙特阿拉伯的 CRC 发病率明显上升，男性和女性在诊断时均处于不同的年龄段和疾病阶段。我们的研究结果表明，有必要找出潜在的风险因素，并制定和实施有效的预防政策和策略，包括筛查计划，以促进早期发现和治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Epidemiology 医学-肿瘤学

CiteScore

4.50

自引率

3.80%

发文量

200

审稿时长

39 days

期刊介绍： Cancer Epidemiology is dedicated to increasing understanding about cancer causes, prevention and control. The scope of the journal embraces all aspects of cancer epidemiology including: • Descriptive epidemiology • Studies of risk factors for disease initiation, development and prognosis • Screening and early detection • Prevention and control • Methodological issues The journal publishes original research articles (full length and short reports), systematic reviews and meta-analyses, editorials, commentaries and letters to the editor commenting on previously published research.