Less invasive surfactant administration versus intubation-surfactant-extubation in preterm infants: a retrospective study.

Q2 Medicine

Medicinski Glasnik Pub Date : 2024-09-01 DOI:10.17392/1726-21-02

Gianluca Dini, Maria Grazia Santini, Federica Celi, Alberto Verrotti

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引用次数: 0

Abstract

Aim: To compare the need for intubation and mechanical ventilation after surfactant delivery between less invasive surfactant administration (LISA)-treated and intubation-surfactant-extubation (IN-SURE)-treated premature infants with respiratory distress syndrome (RDS).

Methods: Retrospective registry-based cohort study enrolled 36 newborns admitted to the Neonatal Intensive Care Unit of the "Santa Maria" Hospital of Terni between 2016 and 2023. As a primary outcome, the need for intubation and mechanical ventilation within 72 hours of life was followed, and major neonatal morbidities and death before discharge as the secondary outcome.

Results: The LISA group and the IN-SURE group included 13 and 23 newborns, respectively. Demographic features showed no significant differences between the two groups. The need for mechanical ventilation in the first 72 hours of life was similar in both groups (p>0.99). There were no significant differences in morbidities.

Conclusion: LISA and INSURE are equally effective modalities for surfactant administration for the treatment of RDS in preterm infants.

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早产儿使用微创表面活性物质与插管-表面活性物质-拔管：一项回顾性研究。

目的：比较少创表面活性物质给药（LISA）治疗和插管-表面活性物质-拔管（IN-SURE）治疗的呼吸窘迫综合征（RDS）早产儿对插管和机械通气的需求：基于登记的回顾性队列研究纳入了2016年至2023年间入住特尔尼 "圣玛丽亚 "医院新生儿重症监护室的36名新生儿。研究以新生儿出生后72小时内是否需要插管和机械通气为主要结果，以新生儿主要疾病和出院前死亡为次要结果：LISA组和IN-SURE组分别有13名和23名新生儿。两组新生儿的人口统计学特征无明显差异。两组新生儿在出生后 72 小时内的机械通气需求相似（P>0.99）。结论：结论：LISA 和 INSURE 是治疗早产儿 RDS 的同样有效的表面活性物质给药方式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicinski Glasnik 医学-医学：内科

CiteScore

2.30

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Medicinski Glasnik (MG) is the official publication (two times per year) of the Medical Association of Zenica-Doboj Canton. Manuscripts that present of original basic and applied research from all fields of medicine (general and clinical practice, and basic medical sciences) are invited.