Theory & practice of Treat-to-Target (T2T) in rheumatoid arthritis.

IF 4.5 2区医学 Q1 RHEUMATOLOGY

Best Practice & Research in Clinical Rheumatology Pub Date : 2024-11-08 DOI:10.1016/j.berh.2024.102018

Jing He, Yifan Wang, Qinghong Liu, Ru Li

引用次数: 0

Abstract

The Treat-to-Target (T2T) approach in rheumatoid arthritis (RA) emphasizes the systematic and regular adjustment of therapy based on predefined targets, typically remission or low disease activity. This review explores the evidence supporting the Treat-to-Target (T2T) strategy, its practical implementation, and its impact on comorbidities in rheumatoid arthritis (RA). Special attention is given to the role of biologics in managing RA, examining whether they effectively treat or reduce associated comorbidities. The review synthesizes findings from randomized controlled trials, meta-analyses, and real-world data to provide a comprehensive overview of T2T's theoretical framework and clinical practice.

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类风湿关节炎的靶向治疗（T2T）理论与实践。

类风湿性关节炎（RA）的 "靶向治疗"（T2T）方法强调根据预先确定的目标（通常是缓解或低疾病活动度）系统而定期地调整治疗方案。本综述探讨了支持 "按目标治疗"（T2T）策略的证据、其实际实施情况及其对类风湿性关节炎（RA）合并症的影响。其中特别关注了生物制剂在控制类风湿关节炎中的作用，研究了生物制剂是否能有效治疗或减少相关合并症。综述综合了随机对照试验、荟萃分析和真实世界数据的研究结果，全面概述了 T2T 的理论框架和临床实践。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Best Practice & Research in Clinical Rheumatology 医学-风湿病学

CiteScore

9.40

自引率

0.00%

发文量

审稿时长

27 days

期刊介绍： Evidence-based updates of best clinical practice across the spectrum of musculoskeletal conditions. Best Practice & Research: Clinical Rheumatology keeps the clinician or trainee informed of the latest developments and current recommended practice in the rapidly advancing fields of musculoskeletal conditions and science. The series provides a continuous update of current clinical practice. It is a topical serial publication that covers the spectrum of musculoskeletal conditions in a 4-year cycle. Each topic-based issue contains around 200 pages of practical, evidence-based review articles, which integrate the results from the latest original research with current clinical practice and thinking to provide a continuous update. Each issue follows a problem-orientated approach that focuses on the key questions to be addressed, clearly defining what is known and not known. The review articles seek to address the clinical issues of diagnosis, treatment and patient management. Management is described in practical terms so that it can be applied to the individual patient. The serial is aimed at the physician in both practice and training.