Hypoglossal Nerve Stimulation Outcomes in Pediatric Trisomy 21 Patients with Overweight or Obesity.

IF 2.2 3区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Laryngoscope Pub Date : 2024-11-09 DOI:10.1002/lary.31832

Jeffrey C Mecham, Hannah Gibbs, Trenton House, Patrick Scheffler

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Abstract

Objectives: To assess the impact of body mass index (BMI) on hypoglossal nerve stimulator (HNS) implantation outcomes in pediatric patients with Down syndrome (DS). We compare outcomes of HNS implantation when comparing children based on overweight or obese status.

Methods: Retrospective cohort study of patients at a single tertiary pediatric hospital who underwent HNS implantation between 2022 and 2024. Patients with DS under 21 years of age at time of implantation were included. One child with Wolf-Hirschhorn syndrome was also included. The main outcome measured was reduction in apnea-hypopnea index (AHI).

Results: Twenty patients were implanted with HNS during the study period. Eleven patients were implanted with a BMI considered overweight and 8 patients with a BMI considered obese. No significant correlation was found between BMI percentile and AHI reduction (r = 0.06, p = 0.8). No significant differences were found between obese and non-obese groups for preoperative AHI, postoperative AHI, or AHI reduction. Both groups responded favorably to HNS therapy with AHI reduction of 83.8% in obese patients and 81.9% in non-obese patients.

Conclusion: We demonstrate no difference in postoperative AHI outcomes when comparing patients with obesity defined as BMI >95th percentile compared to those without.

Level of evidence: 3 Laryngoscope, 2024.

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对体重超重或肥胖的 21 三体综合征小儿患者进行舌下神经刺激的结果。

目的：评估体重指数（BMI）对唐氏综合征儿科患者舌下神经刺激器（HNS）植入效果的影响：评估体重指数（BMI）对唐氏综合征（DS）儿科患者舌下神经刺激器（HNS）植入效果的影响。我们比较了根据超重或肥胖状况对儿童进行舌下神经刺激器植入术的结果：对 2022 年至 2024 年期间在一家三级儿科医院接受 HNS 植入术的患者进行回顾性队列研究。研究纳入了植入时未满 21 岁的 DS 患者。其中还包括一名沃尔夫-赫希霍恩综合征患儿。测量的主要结果是呼吸暂停-低通气指数（AHI）的降低：研究期间，20 名患者植入了 HNS。11 名患者的体重指数被认为超重，8 名患者的体重指数被认为肥胖。BMI 百分位数与 AHI 下降之间没有发现明显的相关性（r = 0.06，p = 0.8）。肥胖组和非肥胖组在术前 AHI、术后 AHI 或 AHI 降低率方面均无明显差异。两组患者均对 HNS 治疗反应良好，肥胖患者的 AHI 降低率为 83.8%，非肥胖患者的 AHI 降低率为 81.9%：我们的研究表明，与非肥胖患者相比，肥胖患者（BMI>95th percentile）的术后 AHI 结果没有差异：3 《喉镜》，2024 年。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Laryngoscope 医学-耳鼻喉科学

CiteScore

6.50

自引率

7.70%

发文量

500

审稿时长

2-4 weeks

期刊介绍： The Laryngoscope has been the leading source of information on advances in the diagnosis and treatment of head and neck disorders since 1890. The Laryngoscope is the first choice among otolaryngologists for publication of their important findings and techniques. Each monthly issue of The Laryngoscope features peer-reviewed medical, clinical, and research contributions in general otolaryngology, allergy/rhinology, otology/neurotology, laryngology/bronchoesophagology, head and neck surgery, sleep medicine, pediatric otolaryngology, facial plastics and reconstructive surgery, oncology, and communicative disorders. Contributions include papers and posters presented at the Annual and Section Meetings of the Triological Society, as well as independent papers, "How I Do It", "Triological Best Practice" articles, and contemporary reviews. Theses authored by the Triological Society’s new Fellows as well as papers presented at meetings of the American Laryngological Association are published in The Laryngoscope. • Broncho-esophagology • Communicative disorders • Head and neck surgery • Plastic and reconstructive facial surgery • Oncology • Speech and hearing defects