Environmental and occupational exposure to organochlorine pesticides associated with Parkinson's disease risk: A systematic review and meta-analysis based on epidemiological evidence

IF 3.9 3区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Public Health Pub Date : 2024-11-09 DOI:10.1016/j.puhe.2024.10.035

Yang Xu , Yan Su , Sheng Cai , Yuanhang Yao , Xianwen Chen

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引用次数: 0

Abstract

Objectives

The purpose of this study was to analyze the association between environmental and occupational organochlorine pesticides (OCPs) exposure and Parkinson's disease (PD) risk.

Study design

Systematic review and meta-analysis.

Methods

A comprehensive search of articles before March 18, 2024, was conducted through PubMed, Cochrane, Embase, Medlin and Web of Science databases, and the relevant data were expressed as odds ratios (OR) and 95 % confidence intervals (CI). Newcastle-Ottawa Scale (NOS) was used to evaluate literature quality. STATA (Version 11.0) was used for analysis.

Results

This meta-analysis included 17 case-control studies. The results showed that OCPs exposure increased PD risk, including seven blood sample assessment exposure (BOCPs) studies (OR = 1.54, 95 % CI = 1.32–1.79) and 10 indirect assessment exposure (IOCPs) studies (OR = 1.19, 95 % CI = 1.04–1.35). Location subgroup analysis showed that OCPs was positively associated with PD risk in Asia, while there was no statistical significance in North America and Europe. The IOCPs functional subclasses subgroup results suggested that organochlorine insecticides were significantly associated with PD risk (OR = 1.18, 95%CI = 1.03–1.37). Study time may be a factor of high heterogeneity in BOCPs. In addition, BOCPs (OR = 1.49, 95%CI = 1.28–1.74) and IOCPs (OR = 1.10, 95%CI = 0.95–1.26) showed different results with PD risk.

Conclusions

Study suggests that OCPs exposure may be a risk factor for PD, but there may be location and OCPs type differences.

查看原文本刊更多论文

与帕金森病风险相关的有机氯杀虫剂环境和职业暴露：基于流行病学证据的系统回顾和荟萃分析。

研究目的本研究旨在分析环境和职业有机氯农药（OCPs）暴露与帕金森病（PD）风险之间的关联：研究设计：系统回顾和荟萃分析：通过PubMed、Cochrane、Embase、Medlin和Web of Science数据库对2024年3月18日之前的文章进行全面检索，相关数据以几率比（OR）和95%置信区间（CI）表示。采用纽卡斯尔-渥太华量表（NOS）评估文献质量。采用 STATA（11.0 版）进行分析：该荟萃分析包括 17 项病例对照研究。结果显示，暴露于 OCPs 会增加 PD 风险，其中包括 7 项血液样本评估暴露（BOCPs）研究（OR = 1.54，95 % CI = 1.32-1.79）和 10 项间接评估暴露（IOCPs）研究（OR = 1.19，95 % CI = 1.04-1.35）。地点亚组分析显示，在亚洲，OCPs 与帕金森病风险呈正相关，而在北美和欧洲则无统计学意义。IOCPs功能亚类分组结果表明，有机氯杀虫剂与PD风险显著相关（OR=1.18，95%CI=1.03-1.37）。研究时间可能是 BOCPs 异质性较高的一个因素。此外，BOCPs（OR = 1.49，95%CI = 1.28-1.74）和IOCPs（OR = 1.10，95%CI = 0.95-1.26）显示出与PD风险不同的结果：研究表明，OCPs暴露可能是PD的一个风险因素，但可能存在地点和OCPs类型的差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Public Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

7.60

自引率

0.00%

发文量

280

审稿时长

37 days

期刊介绍： Public Health is an international, multidisciplinary peer-reviewed journal. It publishes original papers, reviews and short reports on all aspects of the science, philosophy, and practice of public health.