The Interaction of Polygenic Susceptibility to Stress and Childhood Adversity Dimensions Predicts Longitudinal Trajectories of Stress-Sensitivity.

IF 3 2区 心理学 Q2 PSYCHIATRY
Stress and Health Pub Date : 2024-12-01 Epub Date: 2024-11-14 DOI:10.1002/smi.3499
N Barrantes-Vidal, A Gizdic, P Torrecilla, P Mas-Bermejo, T Sheinbaum, S Papiol, G Lafit, I Myin-Germeys, A Rosa, T R Kwapil
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引用次数: 0

Abstract

Stress-sensitivity (SS) is considered a psychobiological trait possibly resulting from the interaction of genetic and environmental factors (GxE). This study examined whether the interaction of SS-related genetic markers with interview-based dimensions of childhood adversity predicted longitudinal trajectories of low versus high SS. Participants were nonclinically-ascertained young adults comprising normative and elevated scores on schizotypy. SS trajectories were defined in a previous report based on three prospective assessments (23.5, 25, 28 years-old) of both retrospective (Perceived Stress Scale; PSS) and momentary (Experience Sampling Methodology; ESM) stress ratings. A total of n = 177 and n = 165 participants with PSS and ESM stress-sensitivity trajectories, respectively, as well as genetic data, were included in the study. GxE effects between a SS Polygenic Risk Score (PRS-SS) and a Genetic Risk Score of the Hypothalamic Pituitary Adrenal axis (GRS-HPA) with childhood adversity dimensions (Intrafamilial Adversity, Threat and Deprivation) on SS trajectories were examined. Threat was the most consistent predictor of persistently high SS. PRS-SS moderated the association of Threat with high-PSS. GRS-HPA moderated the effects of all adversity dimensions on high-PSS. The interaction of PRS-SS with Deprivation and GRS-HPA with Intrafamilial Adversity predicted trajectories of momentary social stress, but the effects were driven by those with lower genetic susceptibility. Genetic-HPA-axis moderates the effects of all adversity dimensions on persistent SS trajectories, as well as PRS-SS and Threat, particularly for retrospective stress measure. The findings highlight the complex interplay between GxE factors and suggest that PSS may better capture SS trait. Including biologically-meaningful GRS indexing SS and adversity dimensions in future studies using comprehensive stress measures would enhance our knowledge on high SS susceptibility and its relationship with diverse psychopathological outcomes.

多基因压力易感性与童年逆境维度的相互作用可预测压力敏感性的纵向轨迹。
压力敏感性(SS)被认为是一种可能由遗传和环境因素(GxE)相互作用产生的心理生物学特征。本研究考察了压力敏感性相关遗传标记与基于访谈的童年逆境维度之间的相互作用是否能预测低压力敏感性与高压力敏感性的纵向轨迹。研究对象为非临床确诊的年轻成年人,包括精神分裂症的标准分和高分。之前的一份报告根据三次前瞻性评估(23.5、25、28 岁)的回顾性(感知压力量表;PSS)和瞬间(经验取样方法;ESM)压力评级对 SS 轨迹进行了定义。共有 n = 177 和 n = 165 名参与者分别具有 PSS 和 ESM 压力敏感性轨迹以及遗传数据。研究考察了 SS 多基因风险评分(PRS-SS)和下丘脑垂体肾上腺轴遗传风险评分(GRS-HPA)与童年逆境维度(家庭内部逆境、威胁和剥夺)之间对 SS 轨迹的 GxE 效应。威胁是预测持续高SS最一致的因素。PRS-SS调节了威胁与高PSS之间的关系。GRS-HPA调节了所有逆境维度对高PSS的影响。PRS-SS与匮乏、GRS-HPA与家庭内部逆境的交互作用预测了瞬间社会压力的轨迹,但这些效应是由遗传易感性较低的人群驱动的。遗传-HPA轴调节了所有逆境维度对持续性社会压力轨迹以及PRS-SS和威胁的影响,尤其是对回顾性压力测量的影响。研究结果凸显了 GxE 因素之间复杂的相互作用,并表明 PSS 可以更好地捕捉 SS 特质。在未来使用综合压力测量方法进行的研究中,将具有生物学意义的GRS纳入SS和逆境维度的指标中,将增进我们对高SS易感性及其与各种心理病理结果之间关系的了解。
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来源期刊
Stress and Health
Stress and Health 医学-精神病学
CiteScore
6.40
自引率
4.90%
发文量
91
审稿时长
>12 weeks
期刊介绍: Stress is a normal component of life and a number of mechanisms exist to cope with its effects. The stresses that challenge man"s existence in our modern society may result in failure of these coping mechanisms, with resultant stress-induced illness. The aim of the journal therefore is to provide a forum for discussion of all aspects of stress which affect the individual in both health and disease. The Journal explores the subject from as many aspects as possible, so that when stress becomes a consideration, health information can be presented as to the best ways by which to minimise its effects.
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