Evolutionarily conserved brainstem architecture enables gravity-guided vertical navigation.

IF 9.8 1区 生物学 Q1 Agricultural and Biological Sciences
PLoS Biology Pub Date : 2024-11-12 eCollection Date: 2024-11-01 DOI:10.1371/journal.pbio.3002902
Yunlu Zhu, Hannah Gelnaw, Franziska Auer, Kyla R Hamling, David E Ehrlich, David Schoppik
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引用次数: 0

Abstract

The sensation of gravity anchors our perception of the environment and is important for navigation. However, the neural circuits that transform gravity into commands for navigation are undefined. We first determined that larval zebrafish (Danio rerio) navigate vertically by maintaining a consistent heading across a series of upward climb or downward dive bouts. Gravity-blind mutant fish swim with more variable heading and excessive veering, leading to less effective vertical navigation. After targeted photoablation of ascending vestibular neurons and spinal projecting midbrain neurons, but not vestibulospinal neurons, vertical navigation was impaired. These data define a sensorimotor circuit that uses evolutionarily conserved brainstem architecture to transform gravitational signals into persistent heading for vertical navigation. The work lays a foundation to understand how vestibular inputs allow animals to move effectively through their environment.

进化保守的脑干结构实现了重力引导的垂直导航。
重力感知是我们感知环境的基础,对导航非常重要。然而,将重力转化为导航指令的神经回路尚未明确。我们首先确定,斑马鱼(Danio rerio)幼体通过在一系列向上攀爬或向下俯冲的过程中保持一致的方向进行垂直导航。重力盲突变型斑马鱼游动时航向变化较大,且过度转向,导致垂直导航效果较差。在对上升前庭神经元和脊髓投射中脑神经元(而非前庭神经元)进行定向光消融后,垂直导航功能受损。这些数据定义了一个传感器运动回路,它利用进化保守的脑干结构将重力信号转化为垂直导航的持续航向。这项工作为了解前庭输入如何使动物在环境中有效移动奠定了基础。
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来源期刊
PLoS Biology
PLoS Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOLOGY
CiteScore
15.40
自引率
2.00%
发文量
359
审稿时长
3-8 weeks
期刊介绍: PLOS Biology is the flagship journal of the Public Library of Science (PLOS) and focuses on publishing groundbreaking and relevant research in all areas of biological science. The journal features works at various scales, ranging from molecules to ecosystems, and also encourages interdisciplinary studies. PLOS Biology publishes articles that demonstrate exceptional significance, originality, and relevance, with a high standard of scientific rigor in methodology, reporting, and conclusions. The journal aims to advance science and serve the research community by transforming research communication to align with the research process. It offers evolving article types and policies that empower authors to share the complete story behind their scientific findings with a diverse global audience of researchers, educators, policymakers, patient advocacy groups, and the general public. PLOS Biology, along with other PLOS journals, is widely indexed by major services such as Crossref, Dimensions, DOAJ, Google Scholar, PubMed, PubMed Central, Scopus, and Web of Science. Additionally, PLOS Biology is indexed by various other services including AGRICOLA, Biological Abstracts, BIOSYS Previews, CABI CAB Abstracts, CABI Global Health, CAPES, CAS, CNKI, Embase, Journal Guide, MEDLINE, and Zoological Record, ensuring that the research content is easily accessible and discoverable by a wide range of audiences.
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