Takayasu's arteritis associated with tuberculosis: a retrospective study.

IF 2 4区医学 Q3 RHEUMATOLOGY

Advances in Rheumatology Pub Date : 2024-11-11 DOI:10.1186/s42358-024-00424-5

Ana Luisa Souza Pedreira, Maria de Lourdes Castro de Oliveira Figueiroa, Mariana Oliveira Miranda, Alisson Regis de Santana, Victor Pereira Mattos, Adriane Sousa da Paz, Camila Cendon Duran, Mittermayer Barreto Santiago

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引用次数: 0

Abstract

Background: Takayasu arteritis (TA) and tuberculosis (TB) share similar histopathological and immunological characteristics. Studies comparing patients with TA with or without active or latent TB infection (LTBI) have revealed some differences in clinical and angiographic profiles. Patient with TA and history of TB exhibited more constitutional symptoms and structural damage to the aorta. This study compared the clinical and radiological features of patients with TA with and without active TB or LTBI.

Methods: We retrospectively analyzed the data of patients with TA at a public tertiary referral outpatient clinic in northeast Brazil from January 2017 to June 2022. Comparisons of clinical features were made according to the presence of TB.

Results: Fifty patients met the eligibility criteria, and a association with TB was identified in 20 (40%) patients (active TB in six and LTBI in 14). There was a predominance of females, and the average age of patients was 40 years. Weight loss was more common in patients with TA and TB (p = 0.005). No significant intergroup differences were noted in terms of comorbidities, medications, erythrocyte sedimentation rates, or C-reactive protein levels. Significant differences were found in abdominal aortic involvement (25% of patients with TA and TB vs. 11.4% in subjects with TA without TB; p = 0.013). Dilations and aneurysms were significantly more common in patients with TA and TB (p = 0.009 and p = 0.027, respectively).

Conclusion: Patients with TA and TB have a higher prevalence of dilatation and aneurysms, most commonly in the abdominal aorta.

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与肺结核有关的高安氏动脉炎：一项回顾性研究。

背景：高安动脉炎（TA）和肺结核（TB）具有相似的组织病理学和免疫学特征。对伴有或不伴有活动性或潜伏性肺结核感染（LTBI）的高安动脉炎患者进行比较后发现，两者在临床和血管造影方面存在一些差异。有肺结核病史的肺结核患者表现出更多的体征和主动脉结构性损伤。本研究比较了伴有和不伴有活动性肺结核或LTBI的TA患者的临床和放射学特征：我们回顾性分析了巴西东北部一家公立三级转诊门诊2017年1月至2022年6月期间TA患者的数据。根据是否存在肺结核对临床特征进行了比较：50名患者符合资格标准，其中20名（40%）患者与肺结核有关（6名患者为活动性肺结核，14名患者为晚期肺结核）。患者以女性居多，平均年龄为 40 岁。体重减轻在 TA 和肺结核患者中更为常见（p = 0.005）。在合并症、药物、红细胞沉降率或 C 反应蛋白水平方面，组间差异不明显。在腹主动脉受累方面存在显著差异（TA合并肺结核患者为25%，TA未合并肺结核患者为11.4%；P = 0.013）。腹主动脉扩张和动脉瘤在 TA 和肺结核患者中更为常见（分别为 p = 0.009 和 p = 0.027）：结论：TA 和肺结核患者的腹主动脉扩张和动脉瘤发病率较高，其中以腹主动脉扩张和动脉瘤最为常见。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Rheumatology Medicine-Rheumatology

CiteScore

4.00

自引率

4.30%

发文量

审稿时长

53 weeks

期刊介绍： Formerly named Revista Brasileira de Reumatologia, the journal is celebrating its 60th year of publication. Advances in Rheumatology is an international, open access journal publishing pre-clinical, translational and clinical studies on all aspects of paediatric and adult rheumatic diseases, including degenerative, inflammatory and autoimmune conditions. The journal is the official publication of the Brazilian Society of Rheumatology and welcomes original research (including systematic reviews and meta-analyses), literature reviews, guidelines and letters arising from published material.