Intrasession repeatability and interobserver reproducibility of ICP Tearscope measurements of tear meniscus height and non-invasive breakup time

IF 4.1 3区医学 Q1 OPHTHALMOLOGY

Contact Lens & Anterior Eye Pub Date : 2024-11-13 DOI:10.1016/j.clae.2024.102333

Ana Rosa Barrio , Mariano González-Pérez , Pedro Arriola-Villalobos , Beatriz Antona

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引用次数: 0

Abstract

Purpose

To examine intrasession repeatability and interobserver reproducibility of tear meniscus height (TMH) and non-invasive tear breakup time (NIBUT) measurements provided by ICP Tearscope, and their agreement with Keratograph 5 M measurements in persons with and without dry eye.

Methods

Participants were 48 individuals with dry eye disease (DED) and 44 healthy controls. To determine intrasession repeatability, two consecutive TMH and NIBUT measurements were carried out by a single experienced examiner using ICP Tearscope. For interobserver reproducibility, a second masked investigator measured TMH and NIBUT on the first image and video captured by the examiner. Keratograph 5 M measurements of both variables were carried out by the same examiner. Repeatability and reproducibility were evaluated through within-subject standard deviation (Sw), coefficient of variation (CoV), intraclass correlation coefficient (ICC) and Bland-Altman plots (bias and limits of agreement (LoA)).

Results

The TMH measurement with ICP Tearscope showed both, a moderate intrasession repeatability (Sw = 0.045, CoV < 19.82 %, ICC > 0.684) and interobserver reproducibility (Sw = 0.032, CoV < 14.09 %, ICC > 0.926).

The NIBUT measurement showed worse intrasession repeatability in the DED group (CoV = 27.53 %) than in the Control group (CoV = 13.31 %). Even though similar Sw, LoA and ICC values were observed in both groups (Sw = 2.55 s and 2.34 s; LoA = −6.60 to 5.18 s and −4.82 to 6.51 s, Control and DED respectively, ICCs > 0.95). Interobserver reproducibility indicated a moderate amount of variability with CoV ≤ 15.01 % recorded in both groups.

Agreement between the two devices was poor. Limits of agreement were not clinically acceptable for TMH (LoA = −0.19 to 0.14 mm and −0.16 to 0.13 mm, Control and DED, respectively) and for NIBUT (LoA = −12.74 to 14.08 s and −12.19 to 12.87 s, Control and DED, respectively).

Conclusions

ICP Tearscope provides TMH and NIBUT measurements that show weak repeatability and moderate interobserver reproducibility. This device is not interchangeable with the Keratograph 5 M.

查看原文本刊更多论文

ICP 泪道镜测量泪液半月板高度和无创破裂时间的会内重复性和观察者间重复性。

目的：研究泪液半月板高度（TMH）和无创泪液破裂时间（NIBUT）的测量结果在干眼症患者和非干眼症患者中的重复性和观察者间的再现性，以及它们与角膜塑形镜 5 M 测量结果的一致性：参与者包括 48 名干眼症 (DED) 患者和 44 名健康对照者。为了确定疗程内的重复性，由一名经验丰富的检查员使用 ICP 泪道镜连续进行两次 TMH 和 NIBUT 测量。为了确定观察者之间的可重复性，第二位蒙面调查员在检查员拍摄的第一张图像和视频上测量了 TMH 和 NIBUT。对这两个变量的角膜 5 M 测量由同一检查者进行。重复性和再现性通过受试者内标准偏差（Sw）、变异系数（CoV）、类内相关系数（ICC）和Bland-Altman图（偏差和一致性界限（LoA））进行评估：使用 ICP Tearscope 进行的 TMH 测量显示出中等程度的会期内重复性（Sw = 0.045，CoV 0.684）和观察者间重复性（Sw = 0.032，CoV 0.926）。DED 组（CoV = 27.53 %）的 NIBUT 测量显示出比对照组（CoV = 13.31 %）更差的区段内重复性。尽管两组观察到相似的 Sw、LoA 和 ICC 值（Sw = 2.55 秒和 2.34 秒；LoA = -6.60 至 5.18 秒和 -4.82 至 6.51 秒，对照组和 DED 组，ICC > 0.95）。观察者之间的再现性显示出中等程度的变异性，两组的 CoV ≤ 15.01%。两种设备之间的一致性较差。在临床上，TMH（LoA = -0.19 至 0.14 mm，对照组和 DED 分别为 -0.16 至 0.13 mm）和 NIBUT（LoA = -12.74 至 14.08 s，对照组和 DED 分别为 -12.19 至 12.87 s）的一致性不合格：ICP Tearscope 提供的 TMH 和 NIBUT 测量结果显示出较低的重复性和中等程度的观察者间重复性。该设备不能与 Keratograph 5 M 互换。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Contact Lens & Anterior Eye OPHTHALMOLOGY-

CiteScore

7.60

自引率

18.80%

发文量

198

审稿时长

55 days

期刊介绍： Contact Lens & Anterior Eye is a research-based journal covering all aspects of contact lens theory and practice, including original articles on invention and innovations, as well as the regular features of: Case Reports; Literary Reviews; Editorials; Instrumentation and Techniques and Dates of Professional Meetings.