Rapid point-of-care pathogen sensing in the post-pandemic era.

Abstract

In the post-pandemic era, interest in on-site technologies capable of rapidly and accurately diagnosing viral or bacterial pathogens has significantly increased. Advances in functional nanomaterials and bioengineering have propelled the progress of point-of-care (POC) sensors, enhancing their speed, specificity, sensitivity, affordability, ease of use, and accuracy. Notably, biosensors that utilize surface-enhanced Raman scattering (SERS) technology have revolutionized the rapid and sensitive diagnosis of biomarkers in pathogenic infections. This review of current POC diagnostics highlights the growing emphasis on immunoassays for swift pathogen analysis, augmented by the integration of deep learning for swift interpretation of complex signals through tailored algorithms.