No association between the early-life gut microbiota and childhood body mass index and body composition.

IF 12.8 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Med Pub Date : 2024-11-07 DOI:10.1016/j.medj.2024.10.015

Christina Egeø Poulsen, Rebecca Vinding, Morten A Rasmussen, Shiraz Shah, Urvish Trivedi, Cristina Leal Rodriguez, Michael L Widdowson, Jie Jiang, Casper S Poulsen, Anders Eliasen, Bo Chawes, Klaus Bønnelykke, Camilla H F Hansen, Søren J Sørensen, Jonathan Thorsen, Jakob Stokholm

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引用次数: 0

Abstract

Background: The gut microbiota has been implicated in adult obesity, but the causality is still unclear. It has been hypothesized that an obesity-prone gut microbiota can be established in infancy, but only few studies have examined the early-life gut microbiota in relation to obesity in childhood, and no consistent associations have been reported. Here, we examine the association between the early-life gut microbiota and body mass index (BMI) development and body composition throughout childhood.

Methods: Gut microbiota from stool were collected from 700 children in the Copenhagen Prospective Studies on Asthma in Childhood₂₀₁₀ (COPSAC₂₀₁₀) cohort at ages of 1 week, 1month, 1 year, 4 years, and 6 years and analyzed by 16S rRNA gene sequencing. Outcomes included BMI World Health Organization (WHO) Z scores (zBMI), overweight (zBMI > 1.04) and obesity (zBMI > 1.64) (0-10 years), and adiposity rebound and body composition from dual-energy X-ray absorptiometry at 6 years.

Findings: The early-life gut microbiota diversity, overall composition, and individual taxon abundances in unsupervised and supervised models were not consistently associated with either current or later BMI Z scores, overweight, obesity, adiposity rebound, or body composition in childhood.

Conclusions: In a deeply characterized longitudinal birth cohort, we did not observe any consistent associations between the early-life gut microbiota and BMI or risk of obesity in later childhood. While this does not conclusively rule out a relationship, it suggests that if such associations exist, they may be more complex and potentially influenced by factors emerging later in life, including lifestyle changes.

Funding: COPSAC is funded by private and public research funds (all listed on www.copsac.com).

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生命早期的肠道微生物群与儿童时期的体重指数和身体成分之间没有关联。

背景：肠道微生物群与成人肥胖有关，但其因果关系仍不清楚。有人假设，易致肥胖的肠道微生物群可在婴儿期建立，但只有少数研究探讨了生命早期的肠道微生物群与儿童肥胖的关系，而且没有报道两者之间存在一致的关联。在此，我们研究了生命早期肠道微生物群与整个儿童期体重指数（BMI）的发育和身体组成之间的关系：从哥本哈根儿童哮喘前瞻性研究（COPSAC2010）队列中的 700 名儿童的 1 周、1 个月、1 岁、4 岁和 6 岁时的粪便中收集肠道微生物群，并通过 16S rRNA 基因测序进行分析。研究结果包括世界卫生组织（WHO）的体重指数 Z 值（zBMI）、超重（zBMI > 1.04）和肥胖（zBMI > 1.64）（0-10 岁），以及 6 岁时双能 X 射线吸收测量法得出的脂肪反弹和身体成分：在无监督和有监督模型中，生命早期的肠道微生物群多样性、总体组成和单个分类群丰度与当前或以后的体重指数 Z 值、超重、肥胖、脂肪反弹或儿童期的身体组成没有一致的关联：在一个特征深刻的纵向出生队列中，我们没有观察到生命早期肠道微生物群与儿童后期体重指数或肥胖风险之间有任何一致的联系。虽然这并不能最终排除两者之间的关系，但它表明，如果存在这种关系，那么这种关系可能会更加复杂，并可能受到生活方式改变等后天因素的影响：COPSAC 由私人和公共研究基金资助（均列于 www.copsac.com）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Med MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

17.70

自引率

0.60%

发文量

102

期刊介绍： Med is a flagship medical journal published monthly by Cell Press, the global publisher of trusted and authoritative science journals including Cell, Cancer Cell, and Cell Reports Medicine. Our mission is to advance clinical research and practice by providing a communication forum for the publication of clinical trial results, innovative observations from longitudinal cohorts, and pioneering discoveries about disease mechanisms. The journal also encourages thought-leadership discussions among biomedical researchers, physicians, and other health scientists and stakeholders. Our goal is to improve health worldwide sustainably and ethically. Med publishes rigorously vetted original research and cutting-edge review and perspective articles on critical health issues globally and regionally. Our research section covers clinical case reports, first-in-human studies, large-scale clinical trials, population-based studies, as well as translational research work with the potential to change the course of medical research and improve clinical practice.