[Research progress on bone repair biomaterials with the function of recruiting endogenous mesenchymal stem cells].

Q3 Medicine
Junjie Zhao, Yuhao Zhao, Yanchuan Pu, Xiyu Wang, Pengfei Huang, Zhaokun Zhang, Haiyan Zhao
{"title":"[Research progress on bone repair biomaterials with the function of recruiting endogenous mesenchymal stem cells].","authors":"Junjie Zhao, Yuhao Zhao, Yanchuan Pu, Xiyu Wang, Pengfei Huang, Zhaokun Zhang, Haiyan Zhao","doi":"10.7507/1002-1892.202407101","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To review the research progress on bone repair biomaterials with the function of recruiting endogenous mesenchymal stem cells (MSCs).</p><p><strong>Methods: </strong>An extensive review of the relevant literature on bone repair biomaterials, particularly those designed to recruit endogenous MSCs, was conducted, encompassing both domestic and international studies from recent years. The construction methods and optimization strategies for these biomaterials were summarized. Additionally, future research directions and focal points concerning this material were proposed.</p><p><strong>Results: </strong>With the advancement of tissue engineering technology, bone repair biomaterials have increasingly emerged as an ideal solution for addressing bone defects. MSCs serve as the most critical \"seed cells\" in bone tissue engineering. Historically, both MSCs and their derived exosomes have been utilized in bone repair biomaterials; however, challenges such as limited sources of MSCs and exosomes, low survival rates, and various other issues have persisted. To address these challenges, researchers are combining growth factors, bioactive peptides, specific aptamers, and other substances with biomaterials to develop constructs that facilitate stem cell recruitment. By optimizing mechanical properties, promoting vascular regeneration, and regulating the microenvironment, it is possible to create effective bone repair biomaterials that enhance stem cell recruitment.</p><p><strong>Conclusion: </strong>In comparison to cytokines, phages, and metal ions, bioactive peptides and aptamers obtained through screening exhibit more specific and targeted recruitment functions. Future development directions for bone repair biomaterials will involve the modification of peptides and aptamers with targeted recruitment capabilities in biological materials, as well as the optimization of the mechanical properties of these materials to enhance vascular regeneration and adjust the microenvironment.</p>","PeriodicalId":23979,"journal":{"name":"中国修复重建外科杂志","volume":"38 11","pages":"1408-1413"},"PeriodicalIF":0.0000,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563741/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中国修复重建外科杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.7507/1002-1892.202407101","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

Abstract

Objective: To review the research progress on bone repair biomaterials with the function of recruiting endogenous mesenchymal stem cells (MSCs).

Methods: An extensive review of the relevant literature on bone repair biomaterials, particularly those designed to recruit endogenous MSCs, was conducted, encompassing both domestic and international studies from recent years. The construction methods and optimization strategies for these biomaterials were summarized. Additionally, future research directions and focal points concerning this material were proposed.

Results: With the advancement of tissue engineering technology, bone repair biomaterials have increasingly emerged as an ideal solution for addressing bone defects. MSCs serve as the most critical "seed cells" in bone tissue engineering. Historically, both MSCs and their derived exosomes have been utilized in bone repair biomaterials; however, challenges such as limited sources of MSCs and exosomes, low survival rates, and various other issues have persisted. To address these challenges, researchers are combining growth factors, bioactive peptides, specific aptamers, and other substances with biomaterials to develop constructs that facilitate stem cell recruitment. By optimizing mechanical properties, promoting vascular regeneration, and regulating the microenvironment, it is possible to create effective bone repair biomaterials that enhance stem cell recruitment.

Conclusion: In comparison to cytokines, phages, and metal ions, bioactive peptides and aptamers obtained through screening exhibit more specific and targeted recruitment functions. Future development directions for bone repair biomaterials will involve the modification of peptides and aptamers with targeted recruitment capabilities in biological materials, as well as the optimization of the mechanical properties of these materials to enhance vascular regeneration and adjust the microenvironment.

[具有招募内源性间充质干细胞功能的骨修复生物材料的研究进展]。
目的综述具有募集内源性间充质干细胞(MSCs)功能的骨修复生物材料的研究进展:方法:广泛综述了近年来国内外关于骨修复生物材料的相关文献,尤其是那些旨在招募内源性间充质干细胞的生物材料。总结了这些生物材料的构建方法和优化策略。此外,还提出了该材料未来的研究方向和重点:结果:随着组织工程技术的发展,骨修复生物材料日益成为解决骨缺损的理想方案。间充质干细胞是骨组织工程中最关键的 "种子细胞"。从历史上看,间充质干细胞及其衍生的外泌体一直被用于骨修复生物材料;然而,间充质干细胞和外泌体来源有限、存活率低等挑战以及其他各种问题一直存在。为了应对这些挑战,研究人员正在将生长因子、生物活性肽、特异性适配体和其他物质与生物材料相结合,开发出促进干细胞募集的构建物。通过优化机械性能、促进血管再生和调节微环境,有可能创造出有效的骨修复生物材料,促进干细胞招募:结论:与细胞因子、噬菌体和金属离子相比,通过筛选获得的生物活性肽和适配体具有更强的特异性和靶向募集功能。骨修复生物材料的未来发展方向将包括在生物材料中修饰具有定向募集功能的多肽和适配体,以及优化这些材料的机械性能,以促进血管再生和调整微环境。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
中国修复重建外科杂志
中国修复重建外科杂志 Medicine-Medicine (all)
CiteScore
0.80
自引率
0.00%
发文量
11334
期刊介绍:
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信