S M Oguche, I B Bosan, I Abubakar, H Abdulaziz, O R Obiako
{"title":"PREVALENCE OF CHRONIC KIDNEY DISEASE AMONG STEADY STATE SICKLE CELL DISEASE ADULT PATIENTS ATTENDING AHMADU BELLO UNIVERSITY TEACHING HOSPITAL, ZARIA.","authors":"S M Oguche, I B Bosan, I Abubakar, H Abdulaziz, O R Obiako","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease is a long-term complication of sickle cell disease (SCD) in adults because of persistent recurrent vaso-occlusive crises, and hyperfiltration. SCD patients are in a steady state, although may be from crises, but may have deranged kidney function.</p><p><strong>Objectives: </strong>This research studied the prevalence of chronic kidney disease among steady-state SCD patients in ABUTH, Zaria.</p><p><strong>Method: </strong>A case-control cross-sectional study of 210 SCD patients and age/sex-matched healthy controls in ABUTH Zaria. The following parameters were assessed among participants: socio-demographic characteristics, facial puffiness, frothiness of urine, urine albumin: creatinine ratio, urine specific gravity, and glomerular filtration rates. Data were analysed using SPSS version 17.0 for Windows, and presented as mean ± SD for nominal variables, and as diagrams for categorical variables. Student t-test and Pearson's Chi-square were used to test for relationship with p<0.05 as significant.</p><p><strong>Results: </strong>The study participants consisted of 113 males and 97 females pairs, with mean ages of 26.8 ± 8.2 vs. 25.7 ± 5.8 years, (p = 0.1) for cases and controls respectively. Prevalence of SCD patients with stage ≤ 3-5 CKD, facial swelling, frothy urine, SG <1.015, albuminuria, urine Hb <13g/dl, and stage were 8.6%,16.2%, 18.0%,33.3%, 47.2%, respectively. All controls had normal kidney functions (p< 0.05).</p><p><strong>Conclusion: </strong>This study has shown the prevalence of 8.6% to 47.2% of features of CKD among steady-state adult SCD patients in ABUTH Zaria.</p>","PeriodicalId":23680,"journal":{"name":"West African journal of medicine","volume":"41 11 Suppl 1","pages":"S44-S45"},"PeriodicalIF":0.0000,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"West African journal of medicine","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Chronic kidney disease is a long-term complication of sickle cell disease (SCD) in adults because of persistent recurrent vaso-occlusive crises, and hyperfiltration. SCD patients are in a steady state, although may be from crises, but may have deranged kidney function.
Objectives: This research studied the prevalence of chronic kidney disease among steady-state SCD patients in ABUTH, Zaria.
Method: A case-control cross-sectional study of 210 SCD patients and age/sex-matched healthy controls in ABUTH Zaria. The following parameters were assessed among participants: socio-demographic characteristics, facial puffiness, frothiness of urine, urine albumin: creatinine ratio, urine specific gravity, and glomerular filtration rates. Data were analysed using SPSS version 17.0 for Windows, and presented as mean ± SD for nominal variables, and as diagrams for categorical variables. Student t-test and Pearson's Chi-square were used to test for relationship with p<0.05 as significant.
Results: The study participants consisted of 113 males and 97 females pairs, with mean ages of 26.8 ± 8.2 vs. 25.7 ± 5.8 years, (p = 0.1) for cases and controls respectively. Prevalence of SCD patients with stage ≤ 3-5 CKD, facial swelling, frothy urine, SG <1.015, albuminuria, urine Hb <13g/dl, and stage were 8.6%,16.2%, 18.0%,33.3%, 47.2%, respectively. All controls had normal kidney functions (p< 0.05).
Conclusion: This study has shown the prevalence of 8.6% to 47.2% of features of CKD among steady-state adult SCD patients in ABUTH Zaria.