Exploration of the pattern of lymph node metastasis in esophageal cancer based on membrane anatomy theory.

IF 2.3 3区医学 Q3 ONCOLOGY

Thoracic Cancer Pub Date : 2024-11-10 DOI:10.1111/1759-7714.15475

Pengjie Yang, Bater Han, Ziqiang Tian, Peng Tang, Qin Yan, Weixin Liu, Xuefeng Zhang, Yongjun Yu, Yong Li

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引用次数: 0

Abstract

Objective: To analyze the pattern of lymph node metastasis in esophageal cancer based on the theory of membrane anatomy.

Methods: A retrospective analysis was conducted on 143 patients who underwent esophageal surgery at the Cancer Hospital of the Chinese Academy of Medical Sciences from March 2021 to March 2022. Lymph node metastasis was observed and categorized according to postoperative T staging. The characteristics and patterns of lymph node metastasis in different regions were observed, and the lymph node metastasis patterns in patients with clinical T3 esophageal cancer were analyzed using membrane anatomy theory.

Results: Among the 143 patients with esophageal squamous cell carcinoma, 21 were treated with surgery alone, while the rest received preoperative adjuvant therapy. A total of 5456 lymph nodes were cleared from the 143 patients, with 204 positive lymph nodes, resulting in a positive rate of 3.74%. In the thoracic lymph node dissection, the metastatic rates exceeded 5% for the following regions: 106recR (17.36%), 106recL (12.5%), 107 (10.42%), and 108 (5.56%) station. When analyzing the abdominal lymph node metastasis, the metastatic rates exceeded 5% for regions 7 (13.19%), 3a (7.64%), 2 (6.94%), and 1 (6.25%) station. Group analysis of patients with esophageal squamous cell carcinoma before postoperative pathological T3 stage revealed an increasing trend in tumor lymph node metastasis rate with later T staging. Lymph node metastasis in region 106recR can occur early, with a metastasis rate of 18.37% in T1 tumors. Analysis of lymph node metastasis characteristics in 103 patients clinically staged as T3 showed that 3966 lymph nodes were cleared, with 186 positive nodes, resulting in a positive rate of 4.69%. Lymph node metastasis rates were higher in regions 106recL, 106recR, 107, 108, 110, 1, 2, 3a, and 7, all exceeding 5%.

Conclusion: The theory of membrane anatomy can effectively explain the pattern of lymph node metastasis in esophageal cancer.

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基于膜解剖学理论的食管癌淋巴结转移模式探讨

目的：根据膜解剖学理论分析食管癌淋巴结转移的模式：基于膜解剖学理论分析食管癌淋巴结转移的规律：方法：对2021年3月至2022年3月在中国医学科学院肿瘤医院接受食管癌手术的143例患者进行回顾性分析。观察淋巴结转移情况，并根据术后T分期进行分类。观察不同区域淋巴结转移的特点和规律，并利用膜解剖学理论分析临床T3食管癌患者的淋巴结转移规律：143例食管鳞癌患者中，21例仅接受了手术治疗，其余患者均接受了术前辅助治疗。143 名患者共清除了 5456 个淋巴结，其中阳性淋巴结 204 个，阳性率为 3.74%。在胸部淋巴结清扫中，以下区域的转移率超过了 5%：106recR（17.36%）、106recL（12.5%）、107（10.42%）和 108（5.56%）站。在分析腹腔淋巴结转移时，7（13.19%）、3a（7.64%）、2（6.94%）和 1（6.25%）站的转移率超过 5%。对术后病理 T3 分期前的食管鳞癌患者进行分组分析发现，肿瘤淋巴结转移率随着 T 分期的推迟呈上升趋势。106recR区域的淋巴结转移可早期发生，T1肿瘤的转移率为18.37%。对临床分期为T3的103例患者的淋巴结转移特征进行分析，结果显示共清除淋巴结3966个，阳性淋巴结186个，阳性率为4.69%。106recL、106recR、107、108、110、1、2、3a 和 7 区淋巴结转移率较高，均超过 5%：结论：膜解剖学理论能有效解释食管癌淋巴结转移的模式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Thoracic Cancer ONCOLOGY-RESPIRATORY SYSTEM

CiteScore

5.20

自引率

3.40%

发文量

439

审稿时长

2 months

期刊介绍： Thoracic Cancer aims to facilitate international collaboration and exchange of comprehensive and cutting-edge information on basic, translational, and applied clinical research in lung cancer, esophageal cancer, mediastinal cancer, breast cancer and other thoracic malignancies. Prevention, treatment and research relevant to Asia-Pacific is a focus area, but submissions from all regions are welcomed. The editors encourage contributions relevant to prevention, general thoracic surgery, medical oncology, radiology, radiation medicine, pathology, basic cancer research, as well as epidemiological and translational studies in thoracic cancer. Thoracic Cancer is the official publication of the Chinese Society of Lung Cancer, International Chinese Society of Thoracic Surgery and is endorsed by the Korean Association for the Study of Lung Cancer and the Hong Kong Cancer Therapy Society. The Journal publishes a range of article types including: Editorials, Invited Reviews, Mini Reviews, Original Articles, Clinical Guidelines, Technological Notes, Imaging in thoracic cancer, Meeting Reports, Case Reports, Letters to the Editor, Commentaries, and Brief Reports.