Isthmin-1 and spexin as promising novel biomarker candidates for invasive ductal breast carcinoma

IF 2.7 4区生物学 Q1 ANATOMY & MORPHOLOGY

Tissue & cell Pub Date : 2024-11-02 DOI:10.1016/j.tice.2024.102601

Ahmet Turk , Tuba Ozcan Metin , Tuncay Kuloglu , Mustafa Yilmaz , Gokhan Artas , I. Hanifi Ozercan , Serhat Hancer

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引用次数: 0

Abstract

Introduction

Breast cancer is one of the most common malignant tumors and a leading cause of cancer-related death in women. Research is focusing on biomarkers linked to breast cancer, particularly two novel proteins: isthmin-1 (ISM-1) and spexin (SPX), which require further investigation.

Material and methods

The study involved 20 healthy controls and 60 patients with invasive ductal carcinoma, categorized into three groups: Grade I (n=20), Grade II (n=20), and Grade III (n=20). Levels of ISM-1 and SPX in tissue were analyzed using immunohistochemistry alongside the clinicopathologic data of patients.

Results

There were no statistically significant differences in age, menopausal status, ER, PR, and Cerb-B2 values across grades (p>0.05). Tumor diameters showed a significant increase in Grade I compared to Grade II (p<0.05), while no significant difference was noted between Grade II and Grade III, although diameters were larger in Grade III compared to Grade I (p<0.05). Notably, ISM-1 immunoreactivity decreased, and SPX immunoreactivity increased significantly across all grades compared to normal tissue (p<0.05), with no significant differences between tumor grades for these markers (p>0.05).

Conclusions

This study presents new findings on ISM-1 and SPX expression in invasive ductal breast carcinoma. The decrease in ISM-1 and increase in SPX suggest a need for further research into the relationship between adipokines and tumor development in breast cancer.

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Isthmin-1和spexin有望成为浸润性导管乳腺癌的新型候选生物标记物。

导言乳腺癌是最常见的恶性肿瘤之一，也是女性因癌症死亡的主要原因。研究重点是与乳腺癌相关的生物标志物，尤其是两种新型蛋白质：isthmin-1（ISM-1）和spexin（SPX），这两种蛋白质需要进一步研究：研究涉及 20 名健康对照者和 60 名浸润性导管癌患者，分为三组：I级（20人）、II级（20人）和III级（20人）。采用免疫组化方法分析组织中 ISM-1 和 SPX 的水平，同时分析患者的临床病理数据：不同级别患者的年龄、绝经状态、ER、PR和Cerb-B2值差异无统计学意义（P>0.05）。肿瘤直径显示，Ⅰ级比Ⅱ级明显增大（P0.05）：本研究提供了关于浸润性导管乳腺癌中ISM-1和SPX表达的新发现。ISM-1的减少和SPX的增加表明，有必要进一步研究脂肪因子与乳腺癌肿瘤发生之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tissue & cell 医学-解剖学与形态学

CiteScore

3.90

自引率

0.00%

发文量

234

期刊介绍： Tissue and Cell is devoted to original research on the organization of cells, subcellular and extracellular components at all levels, including the grouping and interrelations of cells in tissues and organs. The journal encourages submission of ultrastructural studies that provide novel insights into structure, function and physiology of cells and tissues, in health and disease. Bioengineering and stem cells studies focused on the description of morphological and/or histological data are also welcomed. Studies investigating the effect of compounds and/or substances on structure of cells and tissues are generally outside the scope of this journal. For consideration, studies should contain a clear rationale on the use of (a) given substance(s), have a compelling morphological and structural focus and present novel incremental findings from previous literature.