[Intestinal microbiota and chronic heart failure: association and targets of influence of therapy.]

Abstract

The increasing prevalence of chronic heart failure (CHF) among older people is a global problem. Despite the success of treatment, the mortality rate of these patients remains high, resulting in the need to search for new mechanisms of the development and progression of cardiovascular system pathologies, as well as to develop innovative branches of therapy. Considerable recent interest has been directed towards studying changes in the composition of the intestinal microbiota in people with age, its role in development, as well as potential directions for the prevention of cardiovascular diseases and their complications. One of these complications, especially in the elderly, where several lines of relationship with the intestinal microbiota can be traced, is CHF. Pathogenetically, the effect is due to chronic systemic inflammation, as well as the effect of intestinal metabolites on its course. The objective of this literature review is to analyse and systematize existing scientific studies on the relationship between microflora, its changes and chronic heart failure, as well as to study methods of dealing with the links of pathogenesis, which in turn can stop the progression of this complication of SSS diseases. The review presents literature sources published mainly in the period 2019-2024 using PubMed, ScienceDirect, eLIBRARY databases, including review articles, meta-analyses, clinical studies.