Sleep is necessary for experience-dependent sequence plasticity in mouse primary visual cortex.

IF 5.6 2区医学 Q1 Medicine

Sleep Pub Date : 2025-03-11 DOI:10.1093/sleep/zsae262

Nishitha S Hosamane, Adam M Didouchevski, Ayse Malci, Jeffrey P Gavornik, Michael S Sidorov

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引用次数: 0

Abstract

Study objectives: Repeated exposure to familiar visual sequences drives experience-dependent and sequence-specific plasticity in mouse primary visual cortex (V1). Prior work demonstrated a critical role for sleep in consolidating a related but mechanistically distinct form of experience-dependent plasticity in V1. Here, we assessed the role of sleep in consolidation of spatiotemporal sequence learning (sequence plasticity) in mouse V1.

Methods: Visually evoked potentials were recorded in awake, head-fixed mice viewing sequences of four visual stimuli. Each sequence was presented 200 times per session, across multiple sessions, to drive plasticity. The effects of sleep consolidation time and sleep deprivation on plasticity were assessed.

Results: Sequence plasticity occurred in V1 following as little as 1 hour of ad libitum sleep and increased with longer periods of sleep. Sleep deprivation blocked sequence plasticity consolidation, which recovered following subsequent sleep.

Conclusions: Sleep is required for the consolidation of sequence plasticity in mouse V1.

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睡眠是小鼠初级视觉皮层经验依赖序列可塑性的必要条件。

研究目的重复暴露于熟悉的视觉序列会促使小鼠初级视觉皮层（V1）产生经验依赖性和序列特异性可塑性。先前的研究表明，睡眠在巩固 V1 中一种相关但机理上不同的经验依赖可塑性中起着关键作用。在此，我们评估了睡眠在巩固小鼠 V1 时空序列学习（序列可塑性）中的作用：方法：在清醒、头固定的小鼠体内记录视觉诱发电位（VEP），观察四个视觉刺激序列。每个序列每节课呈现200次，跨越多个时段，以驱动可塑性。评估了睡眠巩固时间和睡眠剥夺对可塑性的影响：结果：在自由睡眠一小时的情况下，V1就会出现序列可塑性，并随着睡眠时间的延长而增强。睡眠不足会阻碍序列可塑性的巩固，但在随后的睡眠中又会恢复：结论：小鼠 V1 序列可塑性的巩固需要睡眠。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep Medicine-Neurology (clinical)

CiteScore

8.70

自引率

10.70%

发文量

期刊介绍： SLEEP® publishes findings from studies conducted at any level of analysis, including: Genes Molecules Cells Physiology Neural systems and circuits Behavior and cognition Self-report SLEEP® publishes articles that use a wide variety of scientific approaches and address a broad range of topics. These may include, but are not limited to: Basic and neuroscience studies of sleep and circadian mechanisms In vitro and animal models of sleep, circadian rhythms, and human disorders Pre-clinical human investigations, including the measurement and manipulation of sleep and circadian rhythms Studies in clinical or population samples. These may address factors influencing sleep and circadian rhythms (e.g., development and aging, and social and environmental influences) and relationships between sleep, circadian rhythms, health, and disease Clinical trials, epidemiology studies, implementation, and dissemination research.