Intravoxel incoherent motion MRI to assess feto-placental diffusion and perfusion properties in small fetuses.

IF 9.7 1区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Radiologia Medica Pub Date : 2024-11-14 DOI:10.1007/s11547-024-01918-4

Giada Ercolani, Silvia Capuani, Veronica Celli, Sandra Ciulla, Roberta Ninkova, Marco Gennarini, Valentina Miceli, Robert Grimm, Daniele Di Mascio, Maria Grazia Porpora, Antonella Giancotti, Carlo Catalano, Lucia Manganaro

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引用次数: 0

Abstract

Objectives: To investigate the use of intravoxel incoherent motion (IVIM) to study microperfusion and microstructural characteristics of lungs, brain, and placenta in normal and small fetuses.

Methods: We retrospectively enrolled 30 small fetuses and 82 normal pregnancies who underwent a 1.5-T MRI examination using an IVIM-DWI. Small fetuses were distinguished in small for gestational age (SGA) and "true" fetal growth restriction (FGR). ROIs were placed on the brain parenchyma, lungs, and fetal/maternal placental sides. Differences in perfusion fraction f, diffusion coefficient D, and pseudo-diffusion coefficient D* and their correlation with gestational age (GA) and birth weight (BW) were investigated.

Results: LUNG: f showed significantly lower values (p = 2·10^-7) in small fetuses (SGA + FGR); f discriminates SGA and FGR from normal (p = 0.001; p = 1·10^-6). f increases with GA (p < 0.0001) in the control group; a positive correlation was also obtained in small fetuses, although less significant.

Placenta: FGR showed lower f values than normal ones, in both the fetal (p = 1.4·10^-7) and maternal side (p = 0.001); f discriminates between SGA and FGR (p = 0.03). In small fetuses (SGA + FGR), f correlates positively with BW.

Brain: D values in supratentorial white matter (WM) were significantly higher compared to other regions, in both normal and small fetuses. Small fetuses showed higher D values in occipital WM and pons (p = 0.041; p = 0.027) than in normal. D correlates negatively with GA in the healthy group. No correlation between D and GA was found in SGA + FGR group.

Conclusions: In our study, IVIM-MRI allowed us to detect microstructural and microperfusion changes in the placenta, brain, and lung of small fetuses, noninvasively.

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体内非相干运动核磁共振成像评估小胎儿的胎盘弥散和灌注特性。

目的：研究正常胎儿和小胎儿肺、脑和胎盘的微灌注和微结构特征：研究利用体细胞内非相干运动（IVIM）研究正常胎儿和小胎儿肺、脑和胎盘的微灌注和微结构特征：我们回顾性地选取了30名小胎儿和82名正常孕妇，使用IVIM-DWI进行了1.5T磁共振成像检查。矮小胎儿分为小胎龄（SGA）和 "真正的 "胎儿生长受限（FGR）。在脑实质、肺部和胎儿/母体胎盘侧放置 ROI。研究了灌注分数 f、扩散系数 D 和假扩散系数 D* 的差异及其与胎龄（GA）和出生体重（BW）的相关性：肺：小胎儿（SGA + FGR）的 f 值明显较低（p = 2-10-7）；f 能区分 SGA 和 FGR 与正常胎儿（p = 0.001；p = 1-10-6）：在胎儿（p = 1.4-10-7）和母体（p = 0.001）两侧，FGR 的 f 值均低于正常胎儿（p = 1.4-10-7）；f 可区分 SGA 和 FGR（p = 0.03）。在矮小胎儿（SGA + FGR）中，f 与 BW.Brain.D 值呈正相关：正常胎儿和矮小胎儿脑室上白质（WM）的 D 值均显著高于其他区域。矮小胎儿枕叶白质和脑桥的 D 值（p = 0.041；p = 0.027）高于正常胎儿。在健康组中，D 与 GA 呈负相关。结论：在我们的研究中，IVIM-MRI 使我们能够无创检测小胎儿胎盘、大脑和肺部的微结构和微灌注变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Radiologia Medica 医学-核医学

CiteScore

14.10

自引率

7.90%

发文量

133

审稿时长

4-8 weeks

期刊介绍： Felice Perussia founded La radiologia medica in 1914. It is a peer-reviewed journal and serves as the official journal of the Italian Society of Medical and Interventional Radiology (SIRM). The primary purpose of the journal is to disseminate information related to Radiology, especially advancements in diagnostic imaging and related disciplines. La radiologia medica welcomes original research on both fundamental and clinical aspects of modern radiology, with a particular focus on diagnostic and interventional imaging techniques. It also covers topics such as radiotherapy, nuclear medicine, radiobiology, health physics, and artificial intelligence in the context of clinical implications. The journal includes various types of contributions such as original articles, review articles, editorials, short reports, and letters to the editor. With an esteemed Editorial Board and a selection of insightful reports, the journal is an indispensable resource for radiologists and professionals in related fields. Ultimately, La radiologia medica aims to serve as a platform for international collaboration and knowledge sharing within the radiological community.