Correlation between nova volume flow rate and TOF signal intensity ratio: value in unilateral internal carotid artery occlusion.

IF 9.7 1区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Radiologia Medica Pub Date : 2024-11-12 DOI:10.1007/s11547-024-01917-5

Fabian Wolf, Elisa Colombo, Tilman Schubert, Lara Maria Höbner, Susanne Wegener, Jorn Fierstra, Martina Sebök, Bas van Niftrik, Andreas Luft, Luca Regli, Giuseppe Esposito

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引用次数: 0

Abstract

Background and purposes: Non-invasive optimal vessel analysis quantitative magnetic resonance angiography (NOVA-QMRA) has emerged as a valuable tool to characterize cerebral hemodynamics in intracranial atherosclerotic disease (ICAD). Our aim was to explore the eventual correlation between volume flow rate (VFR) measured via NOVA-QMRA and signal intensity ratio (SIR) of time-of-flight (TOF) MRA in M1- and P2-segments bilaterally in patients with unilateral internal carotid artery (ICA) occlusion.

Materials and methods: Patients with acute, subacute or chronic unilaterall ICA occlusion receiving NOVA-QMRA between June 2019 and June 2021 were retrospectively included. In bilateral M1- and P2-segments VFR was assessed by means of NOVA-QMRA and a region of interest (ROI) was selected to measure TOF SIR. A correlation between TOF SIR and VFR was tested by means of Pearson correlation coefficient. Mean difference of TOF SIR and VFR between ipsilateral (to occluded ICA) and contralateral M1- and P2-segments was analyzed using a two-sided Welch's t test.

Results: Fifty-five patients with unilateral ICA occlusion were included (acute: 28; subacute: 8; chronic: 19). Both ipsilateral (r = 0.536, p < 0.001) and contralateral (r = 0.757, p < 0.001) TOF SIR correlated significantly with NOVA VFR. This observation proved especially true for patients with chronic ICA occlusion. Both VFR (165.18 vs 110.60, p < 0.001) and TOF SIR (4.96 vs 2.70, p < 0.001) were higher in contralateral than ipsilateral M1-segments; whereas, the contrary was observed for P2-segments (VFR 72.35 vs 102.12, p < 0.001, TOF SIR 2.87 vs 3.39, p = 0.016).

Conclusion: The study results showed that TOF SIR significantly correlated with phase-contrast derived flow volume in patients with symptomatic ICA occlusion. This correlation remains the same regardless of the stage of the ischemic stroke (acute vs subacute vs chronic). Furthermore, significantly high VFR and TOF SIR in ipsilateral P2-segments may provide evidence of leptomeningeal collateralization in acute patients. Standardly performed TOF SIR Sequences might be of help for a qualitative evaluation of the flow in M1- and P2-segments in patients with unilateral ICA occlusions. NOVA QMRA allows precise quantitative measurements of the flow in cerebral vessels.

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Nova 容积流速与 TOF 信号强度比之间的相关性：在单侧颈内动脉闭塞中的价值。

背景和目的：无创最佳血管分析定量磁共振血管造影（NOVA-QMRA）已成为描述颅内动脉粥样硬化性疾病（ICAD）脑血流动力学特征的重要工具。我们的目的是探讨单侧颈内动脉（ICA）闭塞患者通过 NOVA-QMRA 测量的体积流量（VFR）与飞行时间（TOF）MRA 在双侧 M1 和 P2 区段的信号强度比（SIR）之间的最终相关性：回顾性纳入2019年6月至2021年6月期间接受NOVA-QMRA检查的急性、亚急性或慢性单侧颈内动脉闭塞患者。通过 NOVA-QMRA 评估双侧 M1 和 P2 节段的 VFR，并选择感兴趣区 (ROI) 测量 TOF SIR。通过皮尔逊相关系数检验 TOF SIR 与 VFR 之间的相关性。采用双侧韦尔奇 t 检验分析同侧（闭塞的 ICA）与对侧 M1 和 P2 节段的 TOF SIR 和 VFR 的平均差异：共纳入 55 名单侧 ICA 闭塞患者（急性：28 人；亚急性：8 人；慢性：19 人）。同侧（r = 0.536，p研究结果表明，TOF SIR 与相位对比得出的有症状的 ICA 闭塞患者的血流量有明显的相关性。无论缺血性卒中处于哪个阶段（急性 vs 亚急性 vs 慢性），这种相关性都是一样的。此外，同侧 P2 区段明显较高的 VFR 和 TOF SIR 可为急性患者提供侧膜侧支的证据。标准的 TOF SIR 序列可能有助于对单侧 ICA 闭塞患者 M1 和 P2 节段的血流进行定性评估。NOVA QMRA 可以对脑血管的血流进行精确的定量测量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Radiologia Medica 医学-核医学

CiteScore

14.10

自引率

7.90%

发文量

133

审稿时长

4-8 weeks

期刊介绍： Felice Perussia founded La radiologia medica in 1914. It is a peer-reviewed journal and serves as the official journal of the Italian Society of Medical and Interventional Radiology (SIRM). The primary purpose of the journal is to disseminate information related to Radiology, especially advancements in diagnostic imaging and related disciplines. La radiologia medica welcomes original research on both fundamental and clinical aspects of modern radiology, with a particular focus on diagnostic and interventional imaging techniques. It also covers topics such as radiotherapy, nuclear medicine, radiobiology, health physics, and artificial intelligence in the context of clinical implications. The journal includes various types of contributions such as original articles, review articles, editorials, short reports, and letters to the editor. With an esteemed Editorial Board and a selection of insightful reports, the journal is an indispensable resource for radiologists and professionals in related fields. Ultimately, La radiologia medica aims to serve as a platform for international collaboration and knowledge sharing within the radiological community.