Krzysztof W Fornalski, Łukasz Adamowski, Ernest Bugała, Rafał Jarmakiewicz, Julianna Krasowska, Łukasz Piotrowski
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引用次数: 0
Abstract
The radiation adaptive response (or radioadaptation) effect is a biophysical and radiobiological phenomenon responsible for, e.g. the enhancement of repair processes, cell cycle and apoptosis regulation or enhancement of antioxidant production in cells/organisms irradiated by low doses and low dose-rates of ionising radiation. This phenomenon, however, is not always present, which creates many problems both for experimenters and theoreticians. Here we propose a comprehensive and complete theoretical model of radioadaptation grounded in mathematical concept of dose- and time-related probability function of the adaptive response appearance. This can be used in the context of two special cases of the adaptive response: the Raper-Yonezawa (priming dose) effect or constant low-dose-rate irradiation (e.g. for high natural background). This complete theoretical approach is supported by Monte Carlo simulations and real-experimental data used for model calibration and validation.
期刊介绍：
Radiation Protection Dosimetry covers all aspects of personal and environmental dosimetry and monitoring, for both ionising and non-ionising radiations. This includes biological aspects, physical concepts, biophysical dosimetry, external and internal personal dosimetry and monitoring, environmental and workplace monitoring, accident dosimetry, and dosimetry related to the protection of patients. Particular emphasis is placed on papers covering the fundamentals of dosimetry; units, radiation quantities and conversion factors. Papers covering archaeological dating are included only if the fundamental measurement method or technique, such as thermoluminescence, has direct application to personal dosimetry measurements. Papers covering the dosimetric aspects of radon or other naturally occurring radioactive materials and low level radiation are included. Animal experiments and ecological sample measurements are not included unless there is a significant relevant content reason.
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