Long-term effects of continuous low dose-rate gamma-ray irradiation on mouse hematopoietic cells.

IF 0.8 4区环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES

Radiation protection dosimetry Pub Date : 2024-11-13 DOI:10.1093/rpd/ncae153

Takanori Yanai, Syouko Kanaiwa-Kudo, Akiko Abe, Mikio Saitou, Shingo Nakamura, Satoshi Tanaka, Jun-Ichiro Komura, Toshiyuki Kobayashi

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引用次数: 0

Abstract

The present work investigates the long-term effects of continuous low dose-rate (20 mGy/day to total doses of 1-8 Gy) gamma-ray exposure on the hematopoietic cells of specific pathogen-free C3H/HeN mice. Peripheral white blood cell (WBC) counts decreased on days 206, 471, and 486, with no significant changes in red blood cell (RBC) and platelet (PLT) counts. The number of colony forming units (CFU-S and CFU-GM) in the bone marrow and spleen from irradiated mice decreased with increasing total dose on day-12 and day-7. The decrease in bone marrow CFU-S persisted throughout the 400-day irradiation period and did not show any recovery up to 210 days postirradiation. These findings suggest that the effects of low-dose-rate (LDR) radiation on the hematopoietic system remain long after the 400-day irradiation was completed. Further investigation showed no significant difference in life spans of non-irradiated W/Wv (c-kit-deficient) mice inoculated with hematopoietic stem cells from irradiated (20 mGy/day for 400 days) or nonirradiated wild-type mice. These results suggest that the effects of continuous low-dose-rate irradiation are more pronounced in hematopoietic stromal cells than in HSCs themselves.

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连续低剂量率伽马射线辐照对小鼠造血细胞的长期影响

本研究调查了连续低剂量率（20 mGy/天，总剂量为1-8 Gy）伽马射线照射对特定无病原体C3H/HeN小鼠造血细胞的长期影响。外周血白细胞（WBC）计数在第206天、第471天和第486天下降，红细胞（RBC）和血小板（PLT）计数无明显变化。在第 12 天和第 7 天，辐照小鼠骨髓和脾脏中的菌落形成单位（CFU-S 和 CFU-GM）数量随着总剂量的增加而减少。骨髓 CFU-S 的减少持续了整个 400 天的辐照期，直到辐照后 210 天也没有恢复。这些研究结果表明，低剂量辐射（LDR）对造血系统的影响在 400 天辐照结束后仍长期存在。进一步调查显示，未接受辐照的W/Wv（c-kit缺陷型）小鼠接种来自接受辐照（每天20毫戈瑞，持续400天）或未接受辐照的野生型小鼠的造血干细胞后，其寿命无明显差异。这些结果表明，持续低剂量辐照对造血基质细胞的影响比对造血干细胞本身的影响更明显。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Radiation protection dosimetry 环境科学-公共卫生、环境卫生与职业卫生

CiteScore

1.40

自引率

10.00%

发文量

223

审稿时长

6-12 weeks

期刊介绍： Radiation Protection Dosimetry covers all aspects of personal and environmental dosimetry and monitoring, for both ionising and non-ionising radiations. This includes biological aspects, physical concepts, biophysical dosimetry, external and internal personal dosimetry and monitoring, environmental and workplace monitoring, accident dosimetry, and dosimetry related to the protection of patients. Particular emphasis is placed on papers covering the fundamentals of dosimetry; units, radiation quantities and conversion factors. Papers covering archaeological dating are included only if the fundamental measurement method or technique, such as thermoluminescence, has direct application to personal dosimetry measurements. Papers covering the dosimetric aspects of radon or other naturally occurring radioactive materials and low level radiation are included. Animal experiments and ecological sample measurements are not included unless there is a significant relevant content reason.