Impact of sleep quality on health-related quality of life domains and the mediating effects of symptoms in people with multiple sclerosis.

IF 3.3 3区医学 Q1 HEALTH CARE SCIENCES & SERVICES

Quality of Life Research Pub Date : 2024-11-13 DOI:10.1007/s11136-024-03836-4

Baye Dagnew, Cynthia A Honan, Laura L Laslett, Bruce V Taylor, Julie Campbell, Leigh Blizzard, Ingrid van der Mei

{"title":"Impact of sleep quality on health-related quality of life domains and the mediating effects of symptoms in people with multiple sclerosis.","authors":"Baye Dagnew, Cynthia A Honan, Laura L Laslett, Bruce V Taylor, Julie Campbell, Leigh Blizzard, Ingrid van der Mei","doi":"10.1007/s11136-024-03836-4","DOIUrl":null,"url":null,"abstract":"Purpose: Many people living with multiple sclerosis (PwMS) experience poor sleep, which is associated with diminished overall health-related quality of life (HRQoL). We quantified associations between sleep quality and HRQoL domains and examined the extent to which other MS symptoms could account for these associations.Methods: In this cross-sectional survey of 1,717 Australians with MS, we used Assessment of Quality of Life (AQoL) 8D and Pittsburgh Sleep Quality Index (PSQI) to assess HRQoL and sleep quality, respectively. Total, direct, and indirect effects of sleep quality on HRQoL domains were determined using mediation regression analysis.Results: Poor sleep quality was significantly associated with all domains of HRQoL, with strongest associations seen for mental health (β=-0.08) and pain (β=-0.11), and weaker associations for independent living (β=-0.05) and senses (β=-0.03). Poor sleep quality had the largest direct effect on mental health (60.8%), happiness (48.7%), and pain (49.7%). MS symptom clusters mostly contributing to indirect effects were \"feelings of anxiety and depression\" for psychosocial, and \"pain and sensory symptoms\" for physical HRQoL super dimensions.Conclusion: Improving sleep could lead to substantial improvements in all HRQoL domains and the improvement in HRQoL could be partially achieved through indirect improvements in sleep on MS symptoms.","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Quality of Life Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11136-024-03836-4","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"HEALTH CARE SCIENCES & SERVICES","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: Many people living with multiple sclerosis (PwMS) experience poor sleep, which is associated with diminished overall health-related quality of life (HRQoL). We quantified associations between sleep quality and HRQoL domains and examined the extent to which other MS symptoms could account for these associations.

Methods: In this cross-sectional survey of 1,717 Australians with MS, we used Assessment of Quality of Life (AQoL) 8D and Pittsburgh Sleep Quality Index (PSQI) to assess HRQoL and sleep quality, respectively. Total, direct, and indirect effects of sleep quality on HRQoL domains were determined using mediation regression analysis.

Results: Poor sleep quality was significantly associated with all domains of HRQoL, with strongest associations seen for mental health (β=-0.08) and pain (β=-0.11), and weaker associations for independent living (β=-0.05) and senses (β=-0.03). Poor sleep quality had the largest direct effect on mental health (60.8%), happiness (48.7%), and pain (49.7%). MS symptom clusters mostly contributing to indirect effects were "feelings of anxiety and depression" for psychosocial, and "pain and sensory symptoms" for physical HRQoL super dimensions.

Conclusion: Improving sleep could lead to substantial improvements in all HRQoL domains and the improvement in HRQoL could be partially achieved through indirect improvements in sleep on MS symptoms.

查看原文本刊更多论文

睡眠质量对多发性硬化症患者健康相关生活质量领域的影响以及症状的中介效应。

目的：许多多发性硬化症患者（PwMS）睡眠质量差，这与整体健康相关生活质量（HRQoL）下降有关。我们对睡眠质量与 HRQoL 领域之间的关联进行了量化，并研究了其他多发性硬化症症状在多大程度上可以解释这些关联：在这项对 1717 名澳大利亚多发性硬化症患者进行的横断面调查中，我们使用生活质量评估 (AQoL) 8D 和匹兹堡睡眠质量指数 (PSQI) 分别评估 HRQoL 和睡眠质量。通过中介回归分析确定了睡眠质量对 HRQoL 领域的总影响、直接影响和间接影响：睡眠质量差与所有 HRQoL 领域都有明显相关性，其中与心理健康（β=-0.08）和疼痛（β=-0.11）的相关性最强，与独立生活（β=-0.05）和感官（β=-0.03）的相关性较弱。睡眠质量差对心理健康（60.8%）、幸福感（48.7%）和疼痛（49.7%）的直接影响最大。对间接影响贡献最大的多发性硬化症症状集群是社会心理方面的 "焦虑和抑郁感"，以及身体方面的 HRQoL 超级维度 "疼痛和感觉症状"：结论：改善睡眠可显著改善所有 HRQoL 领域，而 HRQoL 的改善可部分通过间接改善睡眠对多发性硬化症症状的影响来实现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Quality of Life Research 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.50

自引率

8.60%

发文量

224

审稿时长

3-8 weeks

期刊介绍： Quality of Life Research is an international, multidisciplinary journal devoted to the rapid communication of original research, theoretical articles and methodological reports related to the field of quality of life, in all the health sciences. The journal also offers editorials, literature, book and software reviews, correspondence and abstracts of conferences. Quality of life has become a prominent issue in biometry, philosophy, social science, clinical medicine, health services and outcomes research. The journal''s scope reflects the wide application of quality of life assessment and research in the biological and social sciences. All original work is subject to peer review for originality, scientific quality and relevance to a broad readership. This is an official journal of the International Society of Quality of Life Research.