Novel Applications in Controlled Drug Delivery Systems by Integrating Osmotic Pumps and Magnetic Nanoparticles.

IF 3.4 3区综合性期刊 Q2 CHEMISTRY, ANALYTICAL

Sensors Pub Date : 2024-10-31 DOI:10.3390/s24217042

David Navarro-Tumar, Belén García-Merino, Cristina González-Fernández, Inmaculada Ortiz, Ma-Fresnedo San-Román, Eugenio Bringas

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引用次数: 0

Abstract

The alarming rise in chronic diseases worldwide highlights the urgent need to overcome the limitations of conventional drug delivery systems. In this context, osmotic pumps are able to release drugs by differential osmotic pressure, achieving a controlled rate independent of physiological factors and reducing the dosing frequency. As osmotic pumps are based on the phenomenon of osmosis, the choice of high osmolality draw solutions (DSs) is a critical factor in the successful delivery of the target drug. Therefore, one alternative that has received particular attention is the formulation of DSs with magnetic nanoparticles (MNPs) due to their easy recovery, negligible reverse solute flux (RSF), and their possible tailor-made functionalization to generate high osmotic gradients. In this work, the possible integration of DSs formulated with MNPs in controlled drug delivery systems is discussed for the first time. In particular, the main potential advantages that these novel medical devices could offer, including improved scalability, regeneration, reliability, and enhanced drug delivery performance, are provided and discussed. Thus, the results of this review may demonstrate the potential of MNPs as osmotic agents, which could be useful for advancing the design of osmotic pump-based drug delivery systems.

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通过整合渗透泵和磁性纳米颗粒，实现可控给药系统的新应用。

全球慢性病发病率的惊人增长凸显了克服传统给药系统局限性的迫切需要。在这种情况下，渗透泵能够通过渗透压差释放药物，实现不受生理因素影响的可控速率，并减少给药频率。由于渗透泵以渗透现象为基础，因此选择高渗透压吸取溶液（DSs）是成功输送目标药物的关键因素。因此，磁性纳米粒子（MNPs）是一种备受关注的替代方案，因为它们易于回收、反向溶质通量（RSF）可忽略不计，而且可以进行定制功能化以产生高渗透梯度。在这项研究中，我们首次讨论了在可控给药系统中使用 MNPs 配制 DSs 的可能性。特别是，本文提供并讨论了这些新型医疗器械可能带来的主要潜在优势，包括更好的可扩展性、再生性、可靠性和更强的给药性能。因此，本综述的结果可能会证明 MNPs 作为渗透剂的潜力，这对推进基于渗透泵的给药系统的设计可能很有帮助。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sensors 工程技术-电化学

CiteScore

7.30

自引率

12.80%

发文量

8430

审稿时长

1.7 months

期刊介绍： Sensors (ISSN 1424-8220) provides an advanced forum for the science and technology of sensors and biosensors. It publishes reviews (including comprehensive reviews on the complete sensors products), regular research papers and short notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.