Effect of desmopressin on water and solute circadian rhythms in treatment-naïve children with monosymptomatic enuresis and nocturnal polyuria.

IF 2.6 3区 医学 Q1 PEDIATRICS
Sevasti Karamaria, Lien Dossche, Karlien Dhondt, Karel Everaert, Charlotte Van Herzeele, Johan Vande Walle, Ann Raes
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引用次数: 0

Abstract

Background: Enuresis has a complex pathophysiology involving nocturnal polyuria, reduced bladder capacity at nighttime, and impaired arousability. Desmopressin has long been used as a treatment. However, approximately 30% of children do not fully respond to it, suggesting the involvement of other factors. Solute handling and osmotic excretion have been studied in refractory patients. Nevertheless, data on the effect of desmopressin on these factors are sparse.

Methods: We conducted a post hoc analysis of the SLEEP study. We analyzed the circadian rhythm of solute and water excretion before and after desmopressin in 30 children with monosymptomatic enuresis and nocturnal diuresis > 100% of expected bladder capacity by means of a 24-h urine concentration profile (four daytime and four nighttime urine portions at equivalent time intervals).

Results: Under desmopressin, nocturnal diuresis (rate) and Na/creatinine ratio were significantly lower compared to day values (p = 0.009, p = 0.021, respectively). Osmolality, Na/creatinine, and osmotic excretion showed a significant day vs. night variance only after desmopressin. Nighttime osmotic and sodium excretion were significantly lower (p = 0.004, p = 0.019, respectively) under treatment, indicating the impact of desmopressin on kidney sodium handling. During desmopressin treatment, nocturnal diuresis (rate) showed strong positive correlation with nighttime Na/creatinine (r = 0.436, p < 0.05) and very strongly with nighttime osmotic excretion (r = 0.875, p < 0.0001). However, no correlation was observed with osmolality under desmopressin treatment.

Conclusions: The anti-enuretic and antidiuretic effects of desmopressin therapy are not only related to urinary concentration and nocturnal diuresis but also to the amelioration of circadian rhythms of sodium and solute handling.

去氨加压素对单侧无症状遗尿症和夜间多尿症患儿水和溶质昼夜节律的影响。
背景:遗尿症的病理生理学非常复杂,包括夜间多尿、夜间膀胱容量减少和唤醒能力受损。长期以来,去氨加压素一直被用作治疗方法。然而,约有 30% 的患儿对该疗法没有完全反应,这表明还有其他因素的影响。对难治性患者的溶质处理和渗透排泄进行了研究。然而,有关去氨加压素对这些因素影响的数据却很少:我们对 SLEEP 研究进行了事后分析。方法:我们对 SLEEP 研究进行了事后分析,通过 24 小时尿液浓度曲线(在相同的时间间隔内,白天尿液和夜间尿液各占四份),分析了 30 名单侧无症状遗尿症和夜尿量大于预期膀胱容量 100%的患儿在使用去氨加压素前后的溶质和水排泄昼夜节律:结果:在使用去氨加压素的情况下,夜间利尿(率)和钠/肌酐比值明显低于日间值(分别为 p = 0.009 和 p = 0.021)。只有在使用去氨加压素后,渗透压、钠/肌酐和渗透排泄才显示出明显的昼夜差异。在去氨加压素治疗期间,夜间渗透压和钠排泄量明显降低(分别为 p = 0.004 和 p = 0.019),这表明去氨加压素对肾脏钠处理有影响。在去氨加压素治疗期间,夜间利尿(率)与夜间 Na/肌酐呈强正相关(r = 0.436,p 结论):去氨加压素治疗的抗利尿和抗利尿作用不仅与尿液浓度和夜间利尿有关,还与改善钠和溶质处理的昼夜节律有关。
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来源期刊
Pediatric Nephrology
Pediatric Nephrology 医学-泌尿学与肾脏学
CiteScore
4.70
自引率
20.00%
发文量
465
审稿时长
1 months
期刊介绍: International Pediatric Nephrology Association Pediatric Nephrology publishes original clinical research related to acute and chronic diseases that affect renal function, blood pressure, and fluid and electrolyte disorders in children. Studies may involve medical, surgical, nutritional, physiologic, biochemical, genetic, pathologic or immunologic aspects of disease, imaging techniques or consequences of acute or chronic kidney disease. There are 12 issues per year that contain Editorial Commentaries, Reviews, Educational Reviews, Original Articles, Brief Reports, Rapid Communications, Clinical Quizzes, and Letters to the Editors.
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