Neutrophil Extracellular Traps in Oral Diseases.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2024-11-12 DOI:10.1111/odi.15197

Pengfei Gao, Jun Zhou, Lu Sun, Dayong Liu

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引用次数: 0

Abstract

Objective: To summarize the current knowledge of the neutrophil extracellular traps (NETs) and its critical role in various oral diseases.

Methods: We reviewed the recent research on NETs through PubMed and Web of Science. An analysis of recent research results was summarized from three aspects: NETs induction and formation, functions of NETs, and NETs in oral diseases.

Results: The relationship between neutrophils and NETs is critical to the body's defense against microbial invasion. NETs can effectively combat pathogens with an anti-inflammatory effect and meanwhile it can contribute to inflammation. Moreover, it can synergize with other immune cells to respond to stimuli, such as pathogens, host-derived mediators, and drugs. It was revealed that NETs play different roles to influence various oral diseases like periodontitis, endodontic infection, oral mucosal diseases, maxillofacial tumors, and many other oral diseases.

Conclusion: The balance between the protective and potentially harmful effects of NETs is a key factor in determining the outcome of infections and inflammatory responses. The role of NETs in oral diseases needs to be further studied to enable better understanding of its role in the different oral diseases.

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口腔疾病中的中性粒细胞胞外捕获器

摘要总结中性粒细胞胞外捕获物（NETs）的现有知识及其在各种口腔疾病中的关键作用：我们通过 PubMed 和 Web of Science 查阅了有关 NETs 的最新研究。方法：我们通过 PubMed 和 Web Science 查阅了有关 NETs 的最新研究，并从三个方面对最新研究成果进行了分析总结：方法：我们通过 PubM 和 Web Science 查阅了近期有关 NETs 的研究：结果：中性粒细胞和 NETs 之间的关系对于机体抵御微生物入侵至关重要。结果：中性粒细胞和 NETs 之间的关系对机体抵御微生物入侵至关重要。NETs 可有效对抗病原体，具有抗炎作用，同时它也可导致炎症。此外，它还能与其他免疫细胞协同应对病原体、宿主衍生介质和药物等刺激。研究发现，NETs 在牙周炎、牙髓感染、口腔粘膜疾病、颌面部肿瘤等多种口腔疾病中发挥着不同的作用：结论：NETs 的保护作用和潜在有害作用之间的平衡是决定感染和炎症反应结果的关键因素。NETs在口腔疾病中的作用需要进一步研究，以便更好地了解它在不同口腔疾病中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.