Active-Matrix Metalloproteinase-8, Myeloperoxidase in Relation With Periodontics, Preterm Birth.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2024-11-14 DOI:10.1111/odi.15202

Murat Alan, Timo Sorsa, Pınar Meriç Kantar, Ismo T Raisanen, Önder Gürlek, Burcu Kanmaz, Nurcan Buduneli

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引用次数: 0

Abstract

Objective: To investigate serum, placental levels of active-matrix metalloproteinase-8 (aMMP-8), myeloperoxidase (MPO) in preterm-birth with/without pre-eclampsia and term counterparts in relation with clinical periodontal parameters.

Methods: Clinical periodontal measurements were recorded. Serum and placenta samples were collected during 173 full-term (FT), pre-term (PT) or pre-term complicated by pre-eclampsia (PTPE) deliveries. aMMP-8 levels were measured by IFMA. MPO levels in the serum and placenta samples were determined by ELISA. Data were tested using non-parametric tests.

Results: PTBE group exhibited higher full-mouth probing depth and clinical attachment loss values than the other two groups (p < 0.05). Percentages of sites with plaque and bleeding on probing were lower in the PTBE group than in the other groups (p < 0.05). Serum aMMP-8 and MPO concentrations were higher in PTPE group than in the other groups (p < 0.05). Placenta aMMP-8 level was higher in the control group than in the PTPE group (p < 0.05). There was no significant difference between the groups in the placenta MPO levels (p > 0.05).

Conclusions: Within the limits of this cross-sectional study, it may be suggested that serum aMMP-8 and MPO concentrations together with placenta aMMP-8 levels may be associated with and reflect adverse pregnancy outcomes. Clinical periodontal findings did not reveal significant associations with these proteolytic and oxidative biomarkers.

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活性基质金属蛋白酶-8、髓过氧化物酶与牙周病、早产的关系

目的研究有/无先兆子痫的早产儿和足月儿血清、胎盘中活性基质金属蛋白酶-8（aMMP-8）和髓过氧化物酶（MPO）的水平与临床牙周参数的关系：方法：记录临床牙周测量值。在 173 例足月（FT）、早产（PT）或先兆子痫并发早产（PTPE）分娩过程中采集血清和胎盘样本。血清和胎盘样本中的 MPO 水平通过 ELISA 法测定。采用非参数检验对数据进行检验：结果：PTBE 组的全口探查深度和临床附着丧失值均高于其他两组（P 0.05）：在这项横断面研究的范围内，可以认为血清中aMMP-8和MPO的浓度以及胎盘中aMMP-8的水平可能与不良妊娠结局有关，并反映了不良妊娠结局。临床牙周检查结果显示，这些蛋白水解和氧化生物标志物与妊娠结局并无明显关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.