Association Analysis of Telomere Length and Vision in a Large Community-Based Survey.

IF 1.7 4区医学 Q3 OPHTHALMOLOGY

Ophthalmic epidemiology Pub Date : 2024-11-12 DOI:10.1080/09286586.2024.2422349

Bing Zhang, Yune Zhao

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引用次数: 0

Abstract

Purpose: To investigate whether there is a direct, age-independent association between telomere length and visual acuity decline in a large community-based cohort study.

Methods: Participants older than 40 with linked leukocyte telomere length (LTL) were enrolled in NHANES. LTL was assayed using qPCR from the participants' blood samples. Best corrected visual acuity (BCVA) of the better-seeing eye was analyzed, with visual impairment (VI) defined as BCVA ≥ 20/40. LTL was grouped into quartiles, and its association with BCVA and VI was evaluated after adjusting for covariates.

Results: Among the 4,480 enrolled participants, the weighted means of age, BCVA, and telomere length were 56.1 ± 11.9 years, 0.05 ± 0.08 logMAR, and 5,662 ± 36 base pairs, respectively. The proportion of VI was 2.6%. After adjusting for covariates including sex, ethnicity, education, family poverty income ratio, general health status, hypertension, diabetes, smoking, and body mass index, BCVA was significantly worse in participants with shorter LTL, with a significant trend (p = 0.002). However, after further adjusting for age, the association between LTL and BCVA was no longer significant, without a trend (p = 0.640). No significant association or trend between LTL and VI was found in the stepwise logistic model.

Conclusions: No age-independent association between LTL and BCVA was found. Our study indicates LTL may not serve as a biomarker for age-related visual acuity decline.

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大型社区调查中端粒长度与视力的关联分析

目的：在一项大型社区队列研究中，调查端粒长度与视力下降之间是否存在直接的、与年龄无关的联系：方法：在美国国家健康调查（NHANES）中登记了 40 岁以上、白细胞端粒长度（LTL）相关的参与者。从参与者的血液样本中使用 qPCR 对 LTL 进行检测。对视力较好的眼睛的最佳矫正视力（BCVA）进行分析，视力损伤（VI）定义为 BCVA ≥ 20/40。将LTL分为四等分，在调整协变量后评估其与BCVA和VI的关系：结果：在 4480 名注册参与者中，年龄、BCVA 和端粒长度的加权平均值分别为 56.1 ± 11.9 岁、0.05 ± 0.08 logMAR 和 5,662 ± 36 碱基对。VI比例为2.6%。在调整了包括性别、种族、教育程度、家庭贫困收入比、一般健康状况、高血压、糖尿病、吸烟和体重指数在内的协变量后，LTL较短的参与者的BCVA明显较差，且有显著趋势（p = 0.002）。然而，在进一步调整年龄后，LTL 与 BCVA 之间的关系不再显著，且无趋势（p = 0.640）。在逐步逻辑模型中，LTL与VI之间没有发现明显的关联或趋势：结论：LTL与BCVA之间没有年龄相关性。我们的研究表明，LTL可能不能作为与年龄相关的视力下降的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmic epidemiology 医学-眼科学

CiteScore

3.70

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Ophthalmic Epidemiology is dedicated to the publication of original research into eye and vision health in the fields of epidemiology, public health and the prevention of blindness. Ophthalmic Epidemiology publishes editorials, original research reports, systematic reviews and meta-analysis articles, brief communications and letters to the editor on all subjects related to ophthalmic epidemiology. A broad range of topics is suitable, such as: evaluating the risk of ocular diseases, general and specific study designs, screening program implementation and evaluation, eye health care access, delivery and outcomes, therapeutic efficacy or effectiveness, disease prognosis and quality of life, cost-benefit analysis, biostatistical theory and risk factor analysis. We are looking to expand our engagement with reports of international interest, including those regarding problems affecting developing countries, although reports from all over the world potentially are suitable. Clinical case reports, small case series (not enough for a cohort analysis) articles and animal research reports are not appropriate for this journal.