Role of intestinal testosterone-degrading bacteria and 3/17β-HSD in the pathogenesis of testosterone deficiency-induced hyperlipidemia in males.

IF 7.8 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

npj Biofilms and Microbiomes Pub Date : 2024-11-09 DOI:10.1038/s41522-024-00599-1

Jun Tao, Wen Dai, Yongnan Lyu, Hang Liu, Juan Le, Ting Sun, Qian Yao, Zhiming Zhao, Xuejun Jiang, Yan Li

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Abstract

Testosterone deficiency can cause abnormal lipid metabolism in men, leading to hyperlipidemia. We identified the testosterone-degrading bacterium Pseudomonas nitroreducens in the fecal samples of male patients with hyperlipidemia. Gastric administration of P. nitroreducens in mice led to testosterone deficiency and elevated blood lipid levels. Whole-genome sequencing of P. nitroreducens revealed the presence of 3/17β-hydroxysteroid dehydrogenase (3/17β-HSD), a gene responsible for testosterone degradation, which is also associated with hyperlipidemia. Microbiota analysis of fecal samples collected from 158 patients with hyperlipidemia and 151 controls revealed that the relative abundance of P. nitroreducens and 3/17β-HSD in the fecal samples of patients with hyperlipidemia was significantly higher than that in controls. These results suggest that P. nitroreducens and 3/17β-HSD may be related to the onset of testosterone deficiency-induced hyperlipidemia. Therefore, treatments targeted at eradicating testosterone-degrading bacteria are a potential future option for patients with testosterone-induced hyperlipidemia and should thus be studied further.

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肠道睾酮降解菌和 3/17β-HSD 在男性睾酮缺乏引发的高脂血症发病机制中的作用。

睾酮缺乏会导致男性脂质代谢异常，从而引发高脂血症。我们在男性高脂血症患者的粪便样本中发现了硝酸假单胞菌（Pseudomonas nitroreducens）能降解睾酮。给小鼠灌胃硝酸假单胞菌会导致睾酮缺乏和血脂水平升高。硝化甘油杆菌的全基因组测序发现了 3/17β-羟基类固醇脱氢酶（3/17β-HSD）的存在，该基因负责睾酮的降解，也与高脂血症有关。对 158 名高脂血症患者和 151 名对照组患者的粪便样本进行微生物群分析后发现，高脂血症患者粪便样本中硝酸还原杆菌和 3/17β-HSD 的相对丰度明显高于对照组。这些结果表明，硝基红球菌和 3/17β-HSD 可能与睾酮缺乏引起的高脂血症的发病有关。因此，针对睾酮诱导的高脂血症患者，根除睾酮降解菌的治疗是未来的一个潜在选择，因此应进一步研究。

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来源期刊

npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology

CiteScore

12.10

自引率

3.30%

发文量

审稿时长

9 weeks

期刊介绍： npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.