Neural correlates of sensorimotor adaptation: Thalamic contributions to learning from sensory prediction error

IF 4.7 2区 医学 Q1 NEUROIMAGING
Shirin Mahdavi , Axel Lindner , Carsten Schmidt-Samoa , Anna-Lena Müsch , Peter Dechent , Melanie Wilke
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Abstract

Understanding the neural mechanism of sensorimotor adaptation is essential to reveal how the brain learns from errors, a process driven by sensory prediction errors. While the previous literature has focused on cortical and cerebellar changes, the involvement of the thalamus has received less attention. This functional magnetic resonance imaging study aims to explore the neural substrates of learning from sensory prediction errors with an additional focus on the thalamus. Thirty participants adapted their goal-directed reaches to visual feedback rotations introduced in a step-wise manner, while reporting their predicted visual consequences of their movements intermittently. We found that adaptation initially engaged the cerebellum and fronto-parietal cortical regions, which persisted as adaptation progressed. By the end of adaptation, additional regions within the fronto-parietal cortex and medial pulvinar of the thalamus were recruited. Another finding was the involvement of bilateral medial dorsal nuclei, which showed a positive correlation with the level of motor adaptation. Notably, the gradual shift in the predicted hand movement consequences was associated with activity in the cerebellum, motor cortex and thalamus (ventral lateral, medial dorsal, and medial pulvinar). Our study presents clear evidence for an involvement of the thalamus, both classical ‘motor’ and higher-order nuclei, in error-based motor learning.
感觉运动适应的神经相关性:丘脑对从感觉预测错误中学习的贡献
了解感觉运动适应的神经机制对于揭示大脑如何从错误中学习(这是一个由感觉预测错误驱动的过程)至关重要。以往的文献主要关注大脑皮层和小脑的变化,而丘脑的参与却较少受到关注。这项功能性磁共振成像研究旨在探索从感官预测错误中学习的神经基底,并重点关注丘脑。30 名参与者根据以渐进方式引入的视觉反馈旋转来调整他们的目标指向,同时间歇性地报告他们预测的运动视觉后果。我们发现,适应最初涉及小脑和前顶叶皮层区域,随着适应的进行,这些区域持续存在。到适应期结束时,顶叶前部皮层和丘脑内侧脉络区也被调动起来。另一个发现是双侧内侧背核的参与,这与运动适应水平呈正相关。值得注意的是,预测的手部运动后果的逐渐转变与小脑、运动皮层和丘脑(腹外侧、背内侧和丘脑内侧)的活动有关。我们的研究提供了明确的证据,证明丘脑(包括经典的 "运动 "核和高阶核)参与了基于错误的运动学习。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
NeuroImage
NeuroImage 医学-核医学
CiteScore
11.30
自引率
10.50%
发文量
809
审稿时长
63 days
期刊介绍: NeuroImage, a Journal of Brain Function provides a vehicle for communicating important advances in acquiring, analyzing, and modelling neuroimaging data and in applying these techniques to the study of structure-function and brain-behavior relationships. Though the emphasis is on the macroscopic level of human brain organization, meso-and microscopic neuroimaging across all species will be considered if informative for understanding the aforementioned relationships.
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