Glutamatergic Circuits in the Pedunculopontine Nucleus Modulate Multiple Motor Functions.

IF 5.9 2区 医学 Q1 NEUROSCIENCES
Neuroscience bulletin Pub Date : 2024-11-01 Epub Date: 2024-11-11 DOI:10.1007/s12264-024-01314-y
Yanwang Huang, Shangyi Wang, Qingxiu Wang, Chaowen Zheng, Feng Yang, Lei Wei, Xintong Zhou, Zuoren Wang
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引用次数: 0

Abstract

The functional role of glutamatergic (vGluT2) neurons in the pedunculopontine nucleus (PPN) in modulating motor activity remains controversial. Here, we demonstrated that the activity of vGluT2 neurons in the rostral PPN is correlated with locomotion and ipsilateral head-turning. Beyond these motor functions, we found that these rostral PPN-vGluT2 neurons remarkably respond to salient stimuli. Furthermore, we systematically traced the upstream and downstream projections of these neurons and identified two downstream projections from these neurons to the caudal pontine reticular nucleus/anterior gigantocellular reticular nucleus (PnC/GiA) and the zona incerta (ZI). Our findings indicate that the projections to the PnC/GiA inhibit movement, consistent with 'pause-and-play' behavior, whereas those to the ZI promote locomotion, and others respond to a new 'pause-switch-play' pattern. Collectively, these findings elucidate the multifaceted influence of the PPN on motor functions and provide a robust theoretical framework for understanding its physiological and potential therapeutic implications.

脊髓前核中的谷氨酸能回路调节多种运动功能
足底核(PPN)中的谷氨酸能神经元(vGluT2)在调节运动活动中的功能作用仍存在争议。在这里,我们证明了喙侧 PPN 中 vGluT2 神经元的活动与运动和同侧转头相关。除了这些运动功能外,我们还发现这些喙PPN-vGluT2神经元对显著刺激有明显反应。此外,我们还系统追踪了这些神经元的上下游投射,发现了这些神经元向尾部桥脑网状核/前巨网状核(PnC/GiA)和内侧透明带(ZI)的两个下游投射。我们的研究结果表明,PnC/GiA的投射会抑制运动,这与 "暂停-转换-游戏 "行为一致,而ZI的投射会促进运动,其他投射会对新的 "暂停-转换-游戏 "模式做出反应。总之,这些发现阐明了 PPN 对运动功能的多方面影响,并为理解其生理和潜在治疗意义提供了一个强有力的理论框架。
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来源期刊
Neuroscience bulletin
Neuroscience bulletin NEUROSCIENCES-
CiteScore
7.20
自引率
16.10%
发文量
163
审稿时长
6-12 weeks
期刊介绍: Neuroscience Bulletin (NB), the official journal of the Chinese Neuroscience Society, is published monthly by Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) and Springer. NB aims to publish research advances in the field of neuroscience and promote exchange of scientific ideas within the community. The journal publishes original papers on various topics in neuroscience and focuses on potential disease implications on the nervous system. NB welcomes research contributions on molecular, cellular, or developmental neuroscience using multidisciplinary approaches and functional strategies. We feature full-length original articles, reviews, methods, letters to the editor, insights, and research highlights. As the official journal of the Chinese Neuroscience Society, which currently has more than 12,000 members in China, NB is devoted to facilitating communications between Chinese neuroscientists and their international colleagues. The journal is recognized as the most influential publication in neuroscience research in China.
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