Glycosparvine A, a new indole alkaloid from the leaves of Glycosmis parviflora.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2024-11-09 DOI:10.1080/14786419.2024.2426210

Jing-Ling Ren, Pei-Lian Liu, Hong-Yan Yang, Zhong-Liu Zhou, Zi-Ming Chen, Shou-Yuan Wu

引用次数: 0

Abstract

In the course of our ongoing search for biologically active compounds from medicinal plant, the ethyl acetate extract from the leaves of Glycosmis parviflora (Rutaceae) was investigated. Six compounds including a new indole alkaloid, glycosparvine A (1), and five previously known metabolites (2-6) were identified. The structure of the new compound (1) was unambiguously elucidated by spectroscopic analyses, including 1D/2D NMR spectroscopy and HRESIMS. The absolute configuration of 1 was assigned by comparing its experimental ECD spectra with those reported for similar compound in the literature. Compounds 3 and 6 exhibited moderate inhibitory effects against acetylcholinesterase (AChE) with IC₅₀ values of 35.1 and 2.8 mM, respectively.

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Glycosparvine A，一种来自 Glycosmis parviflora 叶子的新吲哚生物碱。

在我们不断从药用植物中寻找生物活性化合物的过程中，我们研究了芸香科植物 Glycosmis parviflora 叶子的乙酸乙酯提取物。结果发现了六种化合物，包括一种新的吲哚生物碱--甘草次苷 A（1）和五种以前已知的代谢物（2-6）。通过光谱分析，包括一维/二维核磁共振光谱和 HRESIMS，明确地阐明了新化合物（1）的结构。通过比较 1 的实验 ECD 光谱和文献中类似化合物的 ECD 光谱，确定了 1 的绝对构型。化合物 3 和 6 对乙酰胆碱酯酶（AChE）具有中等程度的抑制作用，其 IC50 值分别为 35.1 和 2.8 mM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.