Association of Serum Ferritin Levels with Short-Term Mortality Risk in Sepsis-Associated Acute Kidney Injury: A Retrospective Cohort Study.

IF 2.3 4区医学 Q2 UROLOGY & NEPHROLOGY

Nephron Pub Date : 2024-11-11 DOI:10.1159/000542410

Jie Sun, Ying Qi, Yan Wang, Wenxin Wang, Pengpeng Meng, Changjin Han, Bing Chen

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Abstract

Background: This study aimed to assess the prognostic significance of serum ferritin levels in sepsis-associated acute kidney injury (SA-AKI) and their correlation with short-term mortality. Despite the established predictive value of serum ferritin in various serious diseases, its specific prognostic relevance in SA-AKI remains unexplored. Therefore, this study seeks to fill this research gap by investigating the association between serum ferritin levels and short-term mortality in patients with SA-AKI.

Methods: This retrospective cohort study utilized clinical data from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database, including all patients with SA-AKI admitted to the intensive care unit for the first time. The relationship between serum ferritin levels and 28-day mortality was explored using restricted cubic splines. Kaplan-Meier curves and Cox regression models were employed to evaluate the association between serum ferritin levels and mortality. Subgroup and sensitivity analyses were performed to verify the robustness of the results.

Results: In this study, a total of 878 patients (486 males and 392 females) with a median age of 63.7 years were enrolled. The results indicated that increasing serum ferritin levels were linearly associated with a gradual increase in 28-day mortality rates. Specifically, patients in the highest quartile of serum ferritin had significantly higher 28-day mortality compared to those in the reference group (the first quartile of ferritin levels). After adjusting for various factors, the fully adjusted hazard ratio was 1.92 (95% CI: 1.24-2.96, p = 0.003).

Conclusion: In patients with SA-AKI, higher serum ferritin levels are associated with an increased 28-day mortality rate.

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血清铁蛋白水平与败血症相关急性肾损伤短期死亡风险的关系：一项回顾性队列研究

摘要：研究背景：本研究旨在评估脓毒症相关急性肾损伤（SA-AKI）中血清铁蛋白水平的预后意义及其与短期死亡率的相关性。尽管血清铁蛋白在各种严重疾病中具有公认的预测价值，但其在 SA-AKI 中的具体预后相关性仍未得到探讨。因此，本研究旨在通过调查确诊为 SA-AKI 患者的血清铁蛋白水平与短期死亡率之间的关系来填补这一研究空白：这项回顾性队列研究使用了重症监护医学信息市场-IV（MIMIC-IV）数据库中的临床信息，纳入了所有首次入住重症监护病房（ICU）的 SA-AKI 患者。使用限制性三次样条对血清铁蛋白水平与 28 天死亡率之间的关系进行了探讨。利用 Kaplan Meier 曲线和 Cox 回归模型评估血清铁蛋白水平与死亡率之间的关系。亚组分析用于验证之前结果的稳定性：本研究共纳入 878 名患者（男性 486 人，女性 392 人），中位年龄为 63.7 岁。结果显示，血清铁蛋白水平的增加与 28 天死亡率的逐渐增加呈线性关系。具体来说，最高四分位数组的 28 天死亡率明显高于参照组（铁蛋白第一四分位数）。在对各种因素进行调整后，完全调整后的危险比（HRs）为 1.92（95% CI：1.25~2.97，P=0.003）：在SA-AKI患者中，血清铁蛋白水平越高，28天死亡率越高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nephron UROLOGY & NEPHROLOGY-

CiteScore

5.00

自引率

0.00%

发文量

期刊介绍： ''Nephron'' comprises three sections, which are each under the editorship of internationally recognized leaders and served by specialized Associate Editors. Apart from high-quality original research, ''Nephron'' publishes invited reviews/minireviews on up-to-date topics. Papers undergo an innovative and transparent peer review process encompassing a Presentation Report which assesses and summarizes the presentation of the paper in an unbiased and standardized way.