Cell-Penetrating Peptides in infection and immunization

IF 6.1 1区生物学 Q1 MICROBIOLOGY

Microbiological research Pub Date : 2024-11-05 DOI:10.1016/j.micres.2024.127963

Yongliang Du , Yan Xiong , Zhou Sha , Dong Guo , Beibei Fu , Xiaoyuan Lin , Haibo Wu

{"title":"Cell-Penetrating Peptides in infection and immunization","authors":"Yongliang Du , Yan Xiong , Zhou Sha , Dong Guo , Beibei Fu , Xiaoyuan Lin , Haibo Wu","doi":"10.1016/j.micres.2024.127963","DOIUrl":null,"url":null,"abstract":"<div><div>Bacteria and viruses pose significant threats to human health, as drug molecules and therapeutic agents are often hindered by cell membranes and tissue barriers from reaching intracellular targets. Cell-penetrating peptides (CPPs), composed of 5–30 amino acids, function as molecular shuttles that facilitate the translocation of therapeutic agents across biological barriers. Despite their therapeutic potential, CPPs exhibit limitations, such as insufficient cell specificity, low in vivo stability, reduced delivery efficiency, and limited tolerance under serum conditions. However, intelligent design and chemical modifications can enhance their cell penetration, stability, and selectivity. These advancements could significantly improve CPP-based drug delivery strategies, facilitating both infection treatment and immunization against bacterial and viral diseases. This review provides an overview of the applications of CPPs in various infections and immune diseases, summarizing their mechanisms and the challenges encountered during their application.</div></div>","PeriodicalId":18564,"journal":{"name":"Microbiological research","volume":"290 ","pages":"Article 127963"},"PeriodicalIF":6.1000,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microbiological research","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0944501324003641","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MICROBIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Bacteria and viruses pose significant threats to human health, as drug molecules and therapeutic agents are often hindered by cell membranes and tissue barriers from reaching intracellular targets. Cell-penetrating peptides (CPPs), composed of 5–30 amino acids, function as molecular shuttles that facilitate the translocation of therapeutic agents across biological barriers. Despite their therapeutic potential, CPPs exhibit limitations, such as insufficient cell specificity, low in vivo stability, reduced delivery efficiency, and limited tolerance under serum conditions. However, intelligent design and chemical modifications can enhance their cell penetration, stability, and selectivity. These advancements could significantly improve CPP-based drug delivery strategies, facilitating both infection treatment and immunization against bacterial and viral diseases. This review provides an overview of the applications of CPPs in various infections and immune diseases, summarizing their mechanisms and the challenges encountered during their application.

查看原文本刊更多论文

细胞穿透肽在感染和免疫中的应用。

细菌和病毒对人类健康构成重大威胁，因为药物分子和治疗剂往往受到细胞膜和组织屏障的阻碍，无法到达细胞内靶点。细胞穿透肽（CPPs）由 5-30 个氨基酸组成，具有分子穿梭器的功能，可促进治疗药物穿越生物屏障。尽管具有治疗潜力，但 CPPs 也有其局限性，如细胞特异性不足、体内稳定性低、递送效率降低以及在血清条件下的耐受性有限。然而，智能设计和化学修饰可以增强其细胞穿透性、稳定性和选择性。这些进步可以大大改善基于 CPP 的给药策略，促进感染治疗和针对细菌和病毒疾病的免疫。本综述概述了 CPPs 在各种感染和免疫疾病中的应用，总结了它们的作用机制和应用过程中遇到的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Microbiological research 生物-微生物学

CiteScore

10.90

自引率

6.00%

发文量

249

审稿时长

29 days

期刊介绍： Microbiological Research is devoted to publishing reports on prokaryotic and eukaryotic microorganisms such as yeasts, fungi, bacteria, archaea, and protozoa. Research on interactions between pathogenic microorganisms and their environment or hosts are also covered.