Element analysis applied to investigate acute kidney injury induced by red yeast rice supplement.

IF 1.2 4区医学 Q3 PATHOLOGY

Medical Molecular Morphology Pub Date : 2024-11-13 DOI:10.1007/s00795-024-00411-1

Makoto Abe, Tadayuki Ogawa, Nobuyuki Magome, Yuko Ono, Akihiro Tojo

引用次数: 0

Abstract

Silica nanoparticles are used in functional foods and tablets to increase drug stability and delivery. We investigated a patient with acute kidney injury with Fanconi syndrome after taking functional food tablets made from red yeast rice using low-vacuum scanning electron microscopy (LVSEM) with an element analysis system. Kidney biopsy revealed proximal tubular necrosis and vacuolization with 10-20 nm black granules, which were similar to the silica nanoparticles found in the functional food tablets and urinary samples, as determined via LVSEM with element analysis. Reabsorbed silica nanoparticles induce oxidative stress in the kidney. Element analysis by LVSEM is useful to investigate a possible cause of acute tubular necrosis in patients with Fanconi syndrome.

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应用元素分析法研究红麴补充剂诱发的急性肾损伤。

纳米二氧化硅被用于功能性食品和药片中，以提高药物的稳定性和给药性。我们使用带元素分析系统的低真空扫描电子显微镜（LVSEM）对一名服用红麴功能食品片剂后出现急性肾损伤并伴有范可尼综合征的患者进行了研究。肾脏活检显示近端肾小管坏死和空泡化，并伴有 10-20 纳米的黑色颗粒，经低真空扫描电子显微镜和元素分析系统测定，这些颗粒与功能性食品片剂和尿液样本中发现的纳米二氧化硅颗粒相似。重吸收纳米二氧化硅颗粒会诱发肾脏氧化应激。通过 LVSEM 进行元素分析有助于研究范可尼综合征患者急性肾小管坏死的可能原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical Molecular Morphology 医学-病理学

CiteScore

2.90

自引率

5.60%

发文量

审稿时长

>12 weeks

期刊介绍： Medical Molecular Morphology is an international forum for researchers in both basic and clinical medicine to present and discuss new research on the structural mechanisms and the processes of health and disease at the molecular level. The structures of molecules, organelles, cells, tissues, and organs determine their normal function. Disease is thus best understood in terms of structural changes in these different levels of biological organization, especially in molecules and molecular interactions as well as the cellular localization of chemical components. Medical Molecular Morphology welcomes articles on basic or clinical research in the fields of cell biology, molecular biology, and medical, veterinary, and dental sciences using techniques for structural research such as electron microscopy, confocal laser scanning microscopy, enzyme histochemistry, immunohistochemistry, radioautography, X-ray microanalysis, and in situ hybridization. Manuscripts submitted for publication must contain a statement to the effect that all human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in an appropriate version of the 1964 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study should be omitted.