Association between RANTES/CCL5 levels with Plasmodium infections and malaria severity: a systematic review.

IF 2.4 3区医学 Q3 INFECTIOUS DISEASES

Malaria Journal Pub Date : 2024-11-09 DOI:10.1186/s12936-024-05152-1

Pattamaporn Kwankaew, Aongart Mahittikorn, Wanida Mala, Kwuntida Uthaisar Kotepui, Nsoh Godwin Anabire, Polrat Wilairatana, Manas Kotepui

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引用次数: 0

Abstract

Background: Malaria continues to be a significant global health concern, and developing effective therapeutic strategies requires an understanding of the immune response to the disease. This systematic review synthesized the current body of research on the role of regulated on activation, normal T cell expressed and secreted (RANTES)-in the pathogenesis and disease severity of malaria.

Methods: A systematic review protocol was registered with PROSPERO under the registration number CRD42024535822. The systematic review was conducted following PRISMA guidelines to identify studies examining RANTES levels in individuals infected with Plasmodium species. Searches were performed across multiple databases, including ProQuest, Journals@Ovid, Embase, Scopus, PubMed, and MEDLINE. Further searches were performed in Google Scholar. Quality assessment was done using the Joanna Briggs Institute (JBI) critical appraisal tools. Alterations in RANTES levels in patients with malaria were synthesized narratively.

Results: A comprehensive search of major databases identified 22 studies meeting inclusion criteria, predominantly focusing on Plasmodium falciparum and Plasmodium vivax infections. RANTES levels were found to vary significantly across different severities of malaria, with several studies reporting lower levels in severe cases compared to non-malarial controls. However, inconsistencies were observed in the alterations of RANTES levels between severe and non-severe malaria cases.

Conclusion: Taken together, the finding of this systematic review underscore the complex regulation of RANTES in malaria pathophysiology. Future research should focus on longitudinal assessments to elucidate the dynamic role of RANTES throughout the course of malaria and recovery, to potentially inform the design of novel therapeutic strategies.

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RANTES/CCL5水平与疟原虫感染和疟疾严重程度的关系：系统综述。

背景：疟疾仍然是全球关注的重大健康问题，要制定有效的治疗策略，就必须了解该疾病的免疫反应。本系统综述综述了目前关于正常 T 细胞表达和分泌的活化调节因子（RANTES）在疟疾发病机制和疾病严重程度中的作用的研究：系统综述方案已在 PROSPERO 注册，注册号为 CRD42024535822。该系统综述按照 PRISMA 指南进行，以确定在感染疟原虫的个体中检测 RANTES 水平的研究。在多个数据库中进行了检索，包括 ProQuest、Journals@Ovid、Embase、Scopus、PubMed 和 MEDLINE。此外，还在 Google Scholar 中进行了进一步搜索。采用乔安娜-布里格斯研究所（JBI）的关键评估工具进行质量评估。对疟疾患者体内 RANTES 水平的变化进行了综合叙述：结果：通过对主要数据库的全面检索，发现了 22 项符合纳入标准的研究，主要集中于恶性疟原虫和间日疟原虫感染。研究发现，RANTES水平在不同严重程度的疟疾中差异显著，有几项研究报告称，与非疟疾对照组相比，重症病例中的RANTES水平较低。然而，重症和非重症疟疾病例的 RANTES 水平变化也不一致：综上所述，本系统综述的发现强调了 RANTES 在疟疾病理生理学中的复杂调节作用。未来的研究应侧重于纵向评估，以阐明 RANTES 在整个疟疾和康复过程中的动态作用，从而为设计新型治疗策略提供依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Malaria Journal 医学-寄生虫学

CiteScore

5.10

自引率

23.30%

发文量

334

审稿时长

2-4 weeks

期刊介绍： Malaria Journal is aimed at the scientific community interested in malaria in its broadest sense. It is the only journal that publishes exclusively articles on malaria and, as such, it aims to bring together knowledge from the different specialities involved in this very broad discipline, from the bench to the bedside and to the field.