Pilot study of the effect of surgical menopause on bone mineral density and quality in patients with gynecological malignancies.

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research Pub Date : 2024-11-12 DOI:10.1111/jog.16141

Kanae Matsuno, Kazu Ueda, Mitsuru Saito, Misato Kamii, Akina Tsuda, Ayako Kawabata, Asuka Morikawa, Aikou Okamoto

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引用次数: 0

Abstract

Aim: To investigate the effects of surgical menopause on bone mineral density and bone quality because bilateral salpingo-oophorectomy for the treatment of gynecological malignancies is common even in premenopausal patients. This study is prospective one of bone mineral density and quality measurements after surgery for perimenopausal gynecologic malignancies.

Methods: In 50 women who underwent surgical menopause for a diagnosis of gynecological malignancies, bone mineral density (BMD), blood levels of tartrate-resistant acid phosphatase 5b (TRACP-5b) and bone-specific alkaline phosphatase (BAP) as bone metabolism markers, and urinary pentosidine level as bone quality marker were measured before surgery and at multiple points up to 24 months after surgery.

Results: In a group of 22 patients who did not undergo hormone replacement therapy (HRT) (HRT- group), BMD of the lumbar spine and total hip continued to decrease significantly from 6 months postoperatively. Percentages of changes in BMD progressively increased over time after surgery. TRACP-5b and urinary pentosidine levels significantly increased 6 months postoperatively compared with preoperative levels. Comparisons between 10 patients who underwent HRT (HRT+ group) and the HRT- group revealed significant reductions in the percentage of change in lumbar spine BMD only and TRACP-5b and urinary pentosidine levels 12 months postoperatively in the former group.

Conclusions: In this pilot study, we showed that BMD and bone-related markers are altered in patients with surgical menopause. It also suggested that HRT may reduce these influences on bone metabolism.

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手术绝经对妇科恶性肿瘤患者骨矿物质密度和质量影响的试点研究。

目的：研究绝经手术对骨矿物质密度和骨质量的影响，因为双侧输卵管卵巢切除术治疗妇科恶性肿瘤即使在绝经前患者中也很常见。本研究是围绝经期妇科恶性肿瘤手术后骨矿物质密度和骨质量测量的前瞻性研究：方法：在 50 名因诊断为妇科恶性肿瘤而接受绝经手术的女性中，在手术前和手术后 24 个月内的多个时间点测量骨矿密度（BMD）、作为骨代谢标志物的血液抗酒石酸磷酸酶 5b (TRACP-5b) 和骨特异性碱性磷酸酶 (BAP) 水平，以及作为骨质量标志物的尿戊糖苷水平：在 22 位未接受激素替代疗法（HRT）的患者（HRT- 组）中，腰椎和全髋的 BMD 在术后 6 个月后继续显著下降。术后随着时间的推移，BMD变化的百分比逐渐增加。与术前水平相比，术后 6 个月 TRACP-5b 和尿中喷托西汀水平明显升高。对 10 名接受 HRT 的患者（HRT+ 组）和 HRT- 组进行比较后发现，前者术后 12 个月仅腰椎 BMD 的变化百分比以及 TRACP-5b 和尿中喷托苷水平均显著下降：在这项试验性研究中，我们发现手术绝经患者的 BMD 和骨相关指标发生了改变。结论：在这项试验性研究中，我们发现手术绝经患者的 BMD 和骨相关标志物发生了改变，这也表明激素替代疗法可以减少这些对骨代谢的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obstetrics and Gynaecology Research 医学-妇产科学

CiteScore

3.10

自引率

0.00%

发文量

376

审稿时长

3-6 weeks

期刊介绍： The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.