TP53 mutation may underlie increasing incidence of external auditory canal carcinoma.

IF 0.8 4区医学 Q3 OTORHINOLARYNGOLOGY

Journal of Laryngology and Otology Pub Date : 2025-06-01 DOI:10.1017/S0022215124002159

A Pandya, D Chandrasekharan, K Suchak, J S Virk

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引用次数: 0

Abstract

Background: Primary neoplasm of the external auditory canal has historically been documented to have a low incidence rate of between one and six per million internationally, with UK incidence yet to be officially cited.

Methods: Here, we report a rise in incidence at a single UK trust with seven carcinomas (six T4 external auditory canal squamous cell and one T4 basal cell) reported within an 18-month period. All tumours underwent next generation sequencing.

Results: The cases recorded represented a twofold rise in incidence in reference to international literature from a population-adjusted estimate of 0.5-3 cases for the catchment area to seven cases. All cases were treated with temporal bone resections (n = 7) and with post-operative radiotherapy in six cases. Tumour analysis showed all were TP53 mutant and human papilloma virus (HPV)/P16 negative.

Conclusion: We suggest chronic inflammation and genetic alterations as putative contributory factors in our case series and outline clinical strategies for timely detection of external auditory canal neoplasms.

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TP53突变可能是外耳道癌发病率上升的原因。

背景：外耳道原发肿瘤历史上有文献记载，在国际上发病率很低，在百万分之一到六之间，英国的发病率尚未被正式引用。方法：在这里，我们报告了在18个月的时间内，英国单一信托机构7例癌（6例T4外耳道鳞状细胞癌和1例T4基底细胞癌）的发病率上升。所有肿瘤都进行了下一代测序。结果：与国际文献相比，记录的病例发病率从人口调整后的流域0.5-3例增加到7例，增加了两倍。所有病例均行颞骨切除术（n = 7），其中6例术后放疗。肿瘤分析显示，所有患者均为TP53突变体，人乳头瘤病毒(HPV)/P16阴性。结论：我们认为慢性炎症和遗传改变可能是我们病例系列的促成因素，并概述了及时发现外耳道肿瘤的临床策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Laryngology and Otology 医学-耳鼻喉科学

CiteScore

3.20

自引率

11.80%

发文量

593

审稿时长

3-6 weeks

期刊介绍： The Journal of Laryngology & Otology (JLO) is a leading, monthly journal containing original scientific articles and clinical records in otology, rhinology, laryngology and related specialties. Founded in 1887, JLO is absorbing reading for ENT specialists and trainees. The journal has an international outlook with contributions from around the world, relevant to all specialists in this area regardless of the country in which they practise. JLO contains main articles (original, review and historical), case reports and short reports as well as radiology, pathology or oncology in focus, a selection of abstracts, book reviews, letters to the editor, general notes and calendar, operative surgery techniques, and occasional supplements. It is fully illustrated and has become a definitive reference source in this fast-moving subject area. Published monthly an annual subscription is excellent value for money. Included in the subscription is access to the JLO interactive web site with searchable abstract database of the journal archive back to 1887.