Microneedle patches incorporating zinc-doped mesoporous silica nanoparticles loaded with betamethasone dipropionate for psoriasis treatment.

IF 10.6 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of Nanobiotechnology Pub Date : 2024-11-14 DOI:10.1186/s12951-024-02986-4

Jun Li, Zhiguo Yuan, Shuyu Shi, Xingtao Chen, Shuangshuang Yu, Xiaoshu Qi, Tong Deng, Yifei Zhou, Dan Tang, Saihong Xu, Jue Zhang, Yingfu Jiao, Weifeng Yu, Liya Wang, Liqun Yang, Po Gao

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引用次数: 0

Abstract

Treating psoriasis presents a major clinical challenge because of the limitations associated with traditional topical glucocorticoid therapy. This study introduced a drug delivery system utilizing zinc-doped mesoporous silica nanoparticle (Zn-MSN) and microneedle (MN), designed to enhance drug utilization for prolonged anti-inflammatory and anti-itch effects. The MN system facilitated the transdermal delivery of betamethasone dipropionate (BD), allowing its slow release. The BD@Zn-MSN-MN system promoted the polarization of macrophages towards the anti-inflammatory M2 phenotype, achieving superior anti-inflammatory effects compared to the clinically used BD cream. Additionally, this study demonstrated that BD@Zn-MSN-MN could further alleviate itching in psoriasis-afflicted mice by decreasing the excitability of the transient receptor potential vanilloid V1 (TRPV1) ion channel positive neurons and reducing the release of calcitonin gene-related peptide (CGRP) in the dorsal root ganglion (DRG). These findings offer new insights and effective therapeutic options for the future design of transdermal drug delivery for psoriasis.

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含有掺锌介孔二氧化硅纳米颗粒的微针贴片，内含二丙酸倍他米松，用于治疗牛皮癣。

由于传统的糖皮质激素外用疗法存在局限性，因此治疗银屑病是一项重大的临床挑战。本研究介绍了一种利用掺锌介孔二氧化硅纳米粒子（Zn-MSN）和微针（MN）的给药系统，旨在提高药物利用率，延长抗炎和止痒效果。微针系统有助于二丙酸倍他米松（BD）的透皮给药，使其缓慢释放。BD@Zn-MSN-MN 系统促进巨噬细胞向抗炎 M2 表型极化，与临床使用的 BD 霜相比，抗炎效果更佳。此外，这项研究还证明，BD@Zn-MSN-MN 还能降低瞬时受体电位香草素 V1（TRPV1）离子通道阳性神经元的兴奋性，减少背根神经节（DRG）中降钙素基因相关肽（CGRP）的释放，从而进一步减轻牛皮癣小鼠的瘙痒症状。这些发现为今后设计透皮给药治疗银屑病提供了新的见解和有效的治疗方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nanobiotechnology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

13.90

自引率

4.90%

发文量

493

审稿时长

16 weeks

期刊介绍： Journal of Nanobiotechnology is an open access peer-reviewed journal communicating scientific and technological advances in the fields of medicine and biology, with an emphasis in their interface with nanoscale sciences. The journal provides biomedical scientists and the international biotechnology business community with the latest developments in the growing field of Nanobiotechnology.