Relationship Between the Systemic Immune-Inflammation Index and Deep Venous Thrombosis After Spinal Cord Injury: A Cross-Sectional Study.

IF 4.2 2区医学 Q2 IMMUNOLOGY

Journal of Inflammation Research Pub Date : 2024-11-06 eCollection Date: 2024-01-01 DOI:10.2147/JIR.S491055

Fei Tian, Yuheng Lu, Xinyu Liu, Chenguang Zhao, Xiao Xi, Xu Hu, Yike Xue, Xiaolong Sun, Hua Yuan

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引用次数: 0

Abstract

Purpose: To explore the relationship between the systemic immune-inflammation index (SII) and deep venous thrombosis (DVT) in patients with spinal cord injury (SCI).

Methods: This cross-sectional study included data from 382 participants with SCI. The SII was calculated for all participants. Logistic regression, smooth curve fitting, interaction effects were used to substantiate the research objectives.

Results: The overall prevalence of DVT was 23.1% (22.4% among males, 25.6% among females). A positive association between SII and the risk for DVT was observed (odds ratio 1.39 [95% CI 1.03-1.87]; P=0.032), independent of confounders. Similar patterns of association were observed in the subgroup analysis (P values for interaction, all >0.05). Further sensitivity analyses provided confidence that the results were reliable and unlikely to be substantially altered by unmeasured confounding factors.

Conclusion: Results of the present suggest that higher SII may be associated with DVT in patients with SCI, highlighting a potential link between SII and DVT. These findings underscore the potential of SII as a valuable predictive biomarker for DVT, thus offering a promising avenue for early detection and intervention strategies in patients with SCI.

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脊髓损伤后全身免疫炎症指数与深静脉血栓形成之间的关系：一项横断面研究

目的：探讨脊髓损伤（SCI）患者全身免疫炎症指数（SII）与深静脉血栓形成（DVT）之间的关系：这项横断面研究包括382名脊髓损伤患者的数据。计算了所有参与者的 SII。采用逻辑回归、平滑曲线拟合和交互效应来证实研究目标：深静脉血栓的总发病率为 23.1%（男性为 22.4%，女性为 25.6%）。SII与深静脉血栓风险呈正相关（几率比1.39 [95% CI 1.03-1.87]；P=0.032），不受混杂因素影响。亚组分析中也观察到类似的关联模式（交互作用的 P 值均大于 0.05）。进一步的敏感性分析使我们确信结果是可靠的，不太可能因未测量的混杂因素而发生重大改变：本研究结果表明，较高的 SII 可能与 SCI 患者的深静脉血栓形成有关，突出了 SII 与深静脉血栓形成之间的潜在联系。这些发现强调了 SII 作为深静脉血栓形成有价值的预测性生物标志物的潜力，从而为 SCI 患者的早期检测和干预策略提供了一个前景广阔的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Inflammation Research Immunology and Microbiology-Immunology

CiteScore

6.10

自引率

2.20%

发文量

658

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal that welcomes laboratory and clinical findings on the molecular basis, cell biology and pharmacology of inflammation.