Endodontic Treatment in Patients Undergoing Hematopoietic Stem Cell Transplantation: A Retrospective Cohort Study

IF 3.5 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of endodontics Pub Date : 2025-01-01 DOI:10.1016/j.joen.2024.10.014

Maria Emília Mota DDS , José F. Siqueira Jr DDS, MSc, PhD , Isabela N. Rôças DDS, MSc, PhD , Fábio Abreu Alves DDS, MSc, PhD , Graziella Chagas Jaguar DDS, PhD , Juliana Bertoldi Franco DDS, PhD , Jayr Schmidt Filho MD , Maria Stella Moreira DDS, MSc, PhD

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引用次数: 0

Abstract

Introduction

This study investigated the implications of root canal treatment (RCT) of infected teeth with apical periodontitis (AP) in patients undergoing hematopoietic stem cell transplantation (HSCT).

Methods

One hundred patients were selected. Clinical data, oncologic and endodontic diagnosis and treatment, and type of HSCT were recorded. Data on the exacerbation of AP were investigated. Leukocyte/neutrophil and C-reactive protein levels were evaluated before and after RCT.

Results

One hundred patients underwent HSCT (55% autologous). The need for RCT was identified in 41% of the participants. AP was diagnosed in 75.6% of these patients and large lesions (≥5 mm) occurred in 45.2%. A higher prevalence of AP was observed in males (P = .012). RCT was performed in 54.8% of the individuals and no AP exacerbation, pain, swelling, bacteremia, and need for additional medications was observed. Blood cultures were negative for bacteria and fungi. C-reactive protein levels were ≥1 mg/dL in 54.9% of the individuals 1 month before RCT and <1 mg/dL in 64.6% 6 months after treatment (P > .05).

Conclusions

RCT was effective in controlling infection with no complications in patients undergoing HSCT. Given the potential for exacerbation of endodontic infections, RCT and patient monitoring are essential and highly recommended.

查看原文本刊更多论文

造血干细胞移植患者的牙髓治疗：一项回顾性队列研究。

简介：本研究探讨了根管治疗（RCT）对造血干细胞移植（HSCT）患者根尖牙周炎感染牙齿的影响：本研究探讨了对接受造血干细胞移植（HSCT）的患者进行根管治疗（RCT）的意义：方法：选取 100 名患者。方法：选取 100 例患者，记录其临床数据、肿瘤学和牙髓病学诊断与治疗以及造血干细胞移植类型。对 AP 恶化的数据进行了调查。在造血干细胞移植前后评估了白细胞/中性粒细胞和C反应蛋白（CRP）水平：100名患者接受了造血干细胞移植（55%为自体移植）。41%的患者被确定需要进行 RCT。其中 75.6% 的患者被诊断为 AP，45.2% 的患者出现大面积病变（> 5 毫米）。男性的 AP 患病率更高（P=0.012）。54.8%的患者进行了RCT检查，未发现AP加重、疼痛、肿胀、菌血症和需要额外用药的情况。血液培养的细菌和真菌均为阴性。54.9%的患者在接受 RCT 治疗前 1 个月 CRP 水平大于 1 毫克/分升（0.05）：RCT能有效控制造血干细胞移植患者的感染，且无并发症。考虑到牙髓感染恶化的可能性，RCT 和患者监测至关重要，值得强烈推荐。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of endodontics 医学-牙科与口腔外科

CiteScore

8.80

自引率

9.50%

发文量

224

审稿时长

42 days

期刊介绍： The Journal of Endodontics, the official journal of the American Association of Endodontists, publishes scientific articles, case reports and comparison studies evaluating materials and methods of pulp conservation and endodontic treatment. Endodontists and general dentists can learn about new concepts in root canal treatment and the latest advances in techniques and instrumentation in the one journal that helps them keep pace with rapid changes in this field.