Coinfections and iterative detection of respiratory viruses among 17,689 patients between March 2021 and December 2022 in Southern France

IF 4 3区医学 Q2 VIROLOGY

Journal of Clinical Virology Pub Date : 2024-11-07 DOI:10.1016/j.jcv.2024.105744

Cédric Mantelli , Philippe Colson , Lucile Lesage , Didier Stoupan , Hervé Chaudet , Aurélie Morand , Bernard La Scola , Céline Boschi

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引用次数: 0

Abstract

Objectives

We aimed to describe coinfections and iterative infections with respiratory viruses diagnosed over a 22-month period in 2021–2022 in public university hospitals of the second largest French city.

Material and methods

Respiratory virus infections were diagnosed by qPCR with the Fast Track Diagnostics Respiratory Pathogens 21 on nasopharyngeal swabs collected between 01/03/2021–31/10/2022 and sent for routine diagnosis purpose to our clinical microbiology-virology laboratory at public university hospitals of Marseille, Southern France.

Results

Nasopharyngeal swabs from 17,689 patients were tested, of which 8,133 (46 %) were positive for ≥1 respiratory virus and 1,255 (15%) were co-infected with ≥2 viruses including 213 (2.6 %) with 3–7 viruses. Among them, 1,005 (80 %) were younger than 5 years, and mean age was significantly lower for coinfected than monoinfected patients (6.6 versus 23.8 years; p < 0.0001). Viruses with the highest confection rates were HBoV (97 %), HPeV (97 %), EV (92 %), ADV (68 %), and HCoV-HKU1 (63 %). Iterative infections were observed in 96 patients and they involved 10 different viruses.

Conclusions

Our study points out that coinfections with respiratory viruses vary over time in prevalence, involve majoritarily young children, and may involve concurrent acute infections or acute-on-chronic infections, which deserves further specific studies.

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2021 年 3 月至 2022 年 12 月期间法国南部 17689 名患者的合并感染和呼吸道病毒迭代检测。

目的我们旨在描述法国第二大城市公立大学医院在2021-2022年22个月期间诊断出的呼吸道病毒并发感染和重复感染：对2021年3月1日至2022年10月31日期间采集的鼻咽拭子进行qPCR检测，诊断呼吸道病毒感染，并将其送至法国南部马赛公立大学医院临床微生物学-病毒学实验室进行常规诊断：检测了 17,689 名患者的鼻咽拭子，其中 8,133 人（46%）对≥1 种呼吸道病毒呈阳性，1,255 人（15%）合并感染了≥2 种病毒，包括 213 人（2.6%）感染了 3-7 种病毒。其中 1 005 人（80%）的年龄小于 5 岁，合并感染者的平均年龄明显低于单一感染者（6.6 岁对 23.8 岁；P < 0.0001）。感染率最高的病毒是 HBoV（97%）、HPeV（97%）、EV（92%）、ADV（68%）和 HCoV-HKU1（63%）。在 96 名患者中观察到了迭代感染，涉及 10 种不同的病毒：我们的研究指出，呼吸道病毒合并感染的发病率随时间而变化，主要涉及幼儿，并可能涉及并发急性感染或急性合并慢性感染，值得进一步开展具体研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Virology 医学-病毒学

CiteScore

22.70

自引率

1.10%

发文量

149

审稿时长

24 days

期刊介绍： The Journal of Clinical Virology, an esteemed international publication, serves as the official journal for both the Pan American Society for Clinical Virology and The European Society for Clinical Virology. Dedicated to advancing the understanding of human virology in clinical settings, the Journal of Clinical Virology focuses on disseminating research papers and reviews pertaining to the clinical aspects of virology. Its scope encompasses articles discussing diagnostic methodologies and virus-induced clinical conditions, with an emphasis on practicality and relevance to clinical practice. The journal publishes on topics that include: • new diagnostic technologies • nucleic acid amplification and serologic testing • targeted and metagenomic next-generation sequencing • emerging pandemic viral threats • respiratory viruses • transplant viruses • chronic viral infections • cancer-associated viruses • gastrointestinal viruses • central nervous system viruses • one health (excludes animal health)