Associations of non-insulin-based insulin resistance indices with presence and extent of multi-territorial atherosclerosis: A cross-sectional study.

IF 3.6 3区医学 Q2 PHARMACOLOGY & PHARMACY

Journal of clinical lipidology Pub Date : 2024-10-03 DOI:10.1016/j.jacl.2024.09.011

Yanli Zhang, Mengxing Wang, Xueli Cai, Aoming Jin, Jing Jing, Suying Wang, Xia Meng, Shan Li, Qi Zhou, Xuan Wang, Tiemin Wei, Yongjun Wang, Yuesong Pan

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Abstract

Background: Non-insulin-based insulin resistance (IR) indices, simple and reliable surrogates for IR calculated without insulin level, have been reported to be associated with cardiovascular and cerebrovascular diseases.

Methods: Participants without diabetes from the cross-sectional baseline survey of the PRECISE (Poly-Vascular Evaluation for Cognitive Impairment and Vascular Events) cohort study were included in present study. Non-insulin-based IR indices, including triglyceride and glucose (TyG) index, triglyceride glucose-body mass (TyG-BMI) index, triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, and metabolic score for insulin resistance (METS-IR) index, were calculated and stratified into quartiles. Intracranial, extracranial, coronary, subclavian, aorta, renal, ilio-femoral, and peripheral arteries were also assessed at baseline.

Results: Of 2759 included participants, the average age was 60.9 ( ± 6.6) years, and 1460 (52.9 %) were female. Compared with the first quartile of TyG index, the fourth quartile of TyG index was associated with an increased presence and extent of atherosclerotic plaques (OR, 3.51; 95 %CI,1.30-1.87; cOR, 2.22; 95 %CI,1.76-2.79) and presence and extent of atherosclerotic stenosis (OR, 1.60; 95 %CI,1.24-2.06; cOR, 1.66; 95 %CI,1.30-2.12). Such associations were also observed for the relationship of TyG-BMI index, TG/HDL-C ratio, and METS-IR index with the presence and extent of atherosclerotic plaques and stenosis. Addition of 4 non-insulin-based IR indices to the basic model with traditional risk factors improved the predictive performance of the presence of atherosclerotic plaque and stenosis.

Conclusions: Elevated non-insulin-based IR indices levels were associated with an increased risk of presence and extent of atherosclerotic plaques and stenosis in non-diabetic, older individuals in the PRECISE study. Further, these IR surrogate markers have certain predictive performance to assess the risk of multi-territorial atherosclerosis.

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非胰岛素型胰岛素抵抗指数与多发性动脉粥样硬化的存在和程度的关系：一项横断面研究

背景：据报道，非胰岛素型胰岛素抵抗（IR）指数是在没有胰岛素水平的情况下计算IR的简单而可靠的替代指标，与心脑血管疾病有关：本研究纳入了 PRECISE（认知障碍和血管事件的多血管评估）队列研究横断面基线调查中的非糖尿病参与者。研究人员计算了非胰岛素抵抗指数，包括甘油三酯和葡萄糖（TyG）指数、甘油三酯-葡萄糖-体重（TyG-BMI）指数、甘油三酯-高密度脂蛋白胆固醇（TG/HDL-C）比值以及胰岛素抵抗代谢评分（METS-IR）指数，并将其分为四等分。此外，还对颅内、颅外、冠状动脉、锁骨下动脉、主动脉、肾动脉、髂股动脉和外周动脉进行了基线评估：在 2759 名参与者中，平均年龄为 60.9（± 6.6）岁，1460 人（52.9%）为女性。与TyG指数的第一四分位数相比，TyG指数的第四四分位数与动脉粥样硬化斑块的存在和范围（OR，3.51；95 %CI，1.30-1.87；cOR，2.22；95 %CI，1.76-2.79）以及动脉粥样硬化狭窄的存在和范围（OR，1.60；95 %CI，1.24-2.06；cOR，1.66；95 %CI，1.30-2.12）的增加有关。在TyG-BMI指数、TG/HDL-C比值和METS-IR指数与动脉粥样硬化斑块和狭窄的存在和程度的关系中也观察到了这种关联。在包含传统风险因素的基本模型中加入 4 个非胰岛素型红外指数，可提高对动脉粥样硬化斑块和狭窄的预测能力：结论：在 PRECISE 研究中，非胰岛素型红外指数水平升高与非糖尿病老年患者出现动脉粥样硬化斑块和狭窄的风险及程度增加有关。此外，这些红外替代标志物对评估多发性动脉粥样硬化的风险有一定的预测作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of clinical lipidology 医学-药学

CiteScore

7.00

自引率

6.80%

发文量

209

审稿时长

49 days

期刊介绍： Because the scope of clinical lipidology is broad, the topics addressed by the Journal are equally diverse. Typical articles explore lipidology as it is practiced in the treatment setting, recent developments in pharmacological research, reports of treatment and trials, case studies, the impact of lifestyle modification, and similar academic material of interest to the practitioner. While preference is given to material of immediate practical concern, the science that underpins lipidology is forwarded by expert contributors so that evidence-based approaches to reducing cardiovascular and coronary heart disease can be made immediately available to our readers. Sections of the Journal will address pioneering studies and the clinicians who conduct them, case studies, ethical standards and conduct, professional guidance such as ATP and NCEP, editorial commentary, letters from readers, National Lipid Association (NLA) news and upcoming event information, as well as abstracts from the NLA annual scientific sessions and the scientific forums held by its chapters, when appropriate.