Prognostic impact of the metabolic syndrome and its components in acute type a aortic dissection after surgery: a retrospective study.

IF 1.5 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiothoracic Surgery Pub Date : 2024-11-13 DOI:10.1186/s13019-024-03123-w

Li-Ke Zhang, Hai-Xia Song, Feng Zhang, Zi-Bin Wang, Peng Liu

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引用次数: 0

Abstract

Objective: This study aimed to explore whether metabolic syndrome (MetS) and its components are associated with poor outcomes in patients with acute type A aortic dissection (ATAAD) after surgery.

Methods: This study included 353 patients who had undergone surgery. Demographic and clinical characteristics of the patients were collected. Subgroup, mixed-model regression, score systems, and receiver operating characteristic curve (ROC) analyses were performed.

Results: Overall, 353 inpatients were assigned to the poor outcome group (n = 69) and control group (n = 284) with or without MetS. Compared to the control group, the incidence of MetS was higher in the poor outcome group. Poor outcomes were present in 0%, 4.4%, 12.3%, 47.6%, 71.4%, and 100% of the six groups who met the diagnostic criteria for MetS 0, 1, 2, 3, 4, and 5 times, respectively. For multivariable logistic regression, Body mass index (BMI) quartiles remained risk factors for poor outcomes after adjustment for other risk factors. After adjusting for potential confounding factors, the MetS was found to be an independent risk factor in several models. Assigning a score of one for each component, the AUC was 0.877 (95%CI: 0.823-0.923) in all patients, 0.864 (95%CI: 0.7945-0.935) in MetS, and 0.700 (95%CI: 0.567-0.833) in non-MetS by receiver operating characteristic.

Conclusion: MetS, especially BMI, confer a greater risk of poor outcomes in ATAAD after surgery during the 3-year follow-up.

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新陈代谢综合征及其成分对急性 a 型主动脉夹层术后预后的影响：一项回顾性研究。

目的本研究旨在探讨代谢综合征（MetS）及其组成部分是否与急性A型主动脉夹层（ATAAD）患者术后不良预后有关：本研究纳入了 353 名接受过手术的患者。收集了患者的人口统计学和临床特征。进行了分组、混合模型回归、评分系统和接收器操作特征曲线（ROC）分析：总计353名住院患者被分配到有或没有MetS的不良结局组（69人）和对照组（284人）。与对照组相比，不良结局组的 MetS 发生率更高。在符合 MetS 诊断标准 0 次、1 次、2 次、3 次、4 次和 5 次的六个组别中，分别有 0%、4.4%、12.3%、47.6%、71.4% 和 100% 的人出现不良结局。在多变量逻辑回归中，调整其他风险因素后，身体质量指数（BMI）四分位数仍是不良结局的风险因素。在对潜在的混杂因素进行调整后，发现 MetS 在多个模型中是一个独立的风险因素。根据接收者操作特征，为每个组成部分打 1 分，所有患者的 AUC 为 0.877（95%CI：0.823-0.923），MetS 患者的 AUC 为 0.864（95%CI：0.7945-0.935），非 MetS 患者的 AUC 为 0.700（95%CI：0.567-0.833）：结论：MetS，尤其是 BMI，会增加 ATAAD 患者术后 3 年随访期间出现不良预后的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cardiothoracic Surgery 医学-心血管系统

CiteScore

2.50

自引率

6.20%

发文量

286

审稿时长

4-8 weeks

期刊介绍： Journal of Cardiothoracic Surgery is an open access journal that encompasses all aspects of research in the field of Cardiology, and Cardiothoracic and Vascular Surgery. The journal publishes original scientific research documenting clinical and experimental advances in cardiac, vascular and thoracic surgery, and related fields. Topics of interest include surgical techniques, survival rates, surgical complications and their outcomes; along with basic sciences, pediatric conditions, transplantations and clinical trials. Journal of Cardiothoracic Surgery is of interest to cardiothoracic and vascular surgeons, cardiothoracic anaesthesiologists, cardiologists, chest physicians, and allied health professionals.