Differential vulnerability among cell types in the neurovascular unit: Description and mechanisms.

IF 4.9 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-11-09 DOI:10.1177/0271678X241299960

Allison Brookshier, Patrick Lyden

引用次数: 0

Abstract

Currently, successful preclinical cerebroprotective agents fail to translate effectively into clinical practice suggesting the need for a comprehensive evaluation of all aspects of brain function. Selective vulnerability refers to the specific regional response of the brain following global ischemia, with observed patterns of vulnerability attributed to the distribution of neuronal subtypes and the functions of respective brain regions. Conversely, the concept of differential vulnerability pertains to the cell-type-specific reactions to cerebral ischemia, dictated by the biological characteristics of individual cells. This review aims to explore these vulnerability hypotheses and elucidate potential underlying cellular mechanisms.

查看原文本刊更多论文

神经血管单元中不同类型细胞之间的脆弱性差异：描述与机制

目前，成功的临床前脑保护剂未能有效地应用于临床实践，这表明需要对大脑功能的各个方面进行全面评估。选择性易损性指的是大脑缺血后特定区域的反应，观察到的易损性模式可归因于神经元亚型的分布和各自脑区的功能。相反，差异易损性的概念涉及细胞类型对脑缺血的特异性反应，这是由单个细胞的生物特性决定的。本综述旨在探讨这些易损性假说，并阐明潜在的潜在细胞机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Cerebral Blood Flow and Metabolism 医学-内分泌学与代谢

CiteScore

12.00

自引率

4.80%

发文量

300

审稿时长

3 months

期刊介绍： JCBFM is the official journal of the International Society for Cerebral Blood Flow & Metabolism, which is committed to publishing high quality, independently peer-reviewed research and review material. JCBFM stands at the interface between basic and clinical neurovascular research, and features timely and relevant research highlighting experimental, theoretical, and clinical aspects of brain circulation, metabolism and imaging. The journal is relevant to any physician or scientist with an interest in brain function, cerebrovascular disease, cerebral vascular regulation and brain metabolism, including neurologists, neurochemists, physiologists, pharmacologists, anesthesiologists, neuroradiologists, neurosurgeons, neuropathologists and neuroscientists.