Association between blood lead levels and serum creatinine: a cross-sectional study.

IF 1.8 4区医学 Q3 UROLOGY & NEPHROLOGY

International Urology and Nephrology Pub Date : 2024-11-10 DOI:10.1007/s11255-024-04277-1

Qi Su, Wangjuejue Zhang, Dingqi Li, Xiucheng Lan, Leilei Guo, Diang Chen

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引用次数: 0

Abstract

Purpose: The aim of this cross-sectional study was to investigate the association between blood lead levels and serum creatinine.

Methods: In the present study, sample data were derived from the National Health and Nutrition Examination Survey (NHANES) 2015-2018 of participants with complete data of blood lead levels and serum creatinine. Multivariate linear regression models were used to examine the association between blood lead levels and serum creatinine. The nonlinear connection was described using fitted smoothing curves and threshold effect analysis. Furthermore, subgroup analyses and interaction tests were performed.

Results: A total of 9026 participants were enrolled in this study, and the mean serum creatinine for all subjects was 0.86 ± 0.34 mg/dL. When blood lead levels were divided into quartiles, it was found that participants' serum creatinine levels gradually increased with increasing blood lead levels (Q1: 0.77 ± 0.19 mg/dL, Q2: 0.84 ± 0.23 mg/ dL, Q3: 0.89 ± 0.34 mg/dL, Q4: 0.94 ± 0.50 mg/dL). Compared to the lowest serum quartile, the highest quartile of blood lead levels had a positive correlation with serum creatinine in the fully adjusted model (β = 0.05 95% CI 0.01-0.08). Smooth curve fittings and threshold effect analysis showed an inverted J-shaped nonlinear relationship between blood lead levels and serum creatinine, with an inflection point of 3.10 (μg/dL). Subgroup analyses and interaction tests revealed that diabetes mellitus impacted the relationship between serum creatinine and blood lead levels.

Conclusion: This study suggests a positive correlation between blood lead levels and serum creatinine.

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血铅水平与血清肌酐之间的关系：一项横断面研究。

目的：本横断面研究旨在探讨血铅水平与血清肌酐之间的关联：在本研究中，样本数据来源于2015-2018年美国国家健康与营养调查（NHANES）中血铅水平和血清肌酐数据完整的参与者。研究采用多变量线性回归模型来检验血铅水平与血清肌酐之间的关联。使用拟合平滑曲线和阈值效应分析来描述非线性联系。此外，还进行了亚组分析和交互检验：共有 9026 人参与了这项研究，所有受试者的平均血清肌酐为 0.86 ± 0.34 mg/dL。将血铅水平分为四等分，发现参与者的血清肌酐水平随着血铅水平的升高而逐渐升高（Q1：0.77 ± 0.19 mg/dL；Q2：0.84 ± 0.23 mg/dL；Q3：0.89 ± 0.34 mg/dL；Q4：0.94 ± 0.50 mg/dL）。在完全调整模型中，与血清最低四分位数相比，血铅水平最高四分位数与血清肌酐呈正相关（β = 0.05 95% CI 0.01-0.08）。平滑曲线拟合和阈值效应分析表明，血铅水平与血清肌酐之间存在倒 "J "形的非线性关系，拐点为 3.10（μg/dL）。分组分析和交互检验显示，糖尿病影响血清肌酐与血铅水平之间的关系：本研究表明，血铅水平与血清肌酐之间存在正相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Urology and Nephrology 医学-泌尿学与肾脏学

CiteScore

3.40

自引率

5.00%

发文量

329

审稿时长

1.7 months

期刊介绍： International Urology and Nephrology publishes original papers on a broad range of topics in urology, nephrology and andrology. The journal integrates papers originating from clinical practice.