Association of Adult Atopic Dermatitis with Impaired Oral Health and Oral Dysbiosis: A Case-Control Study.

IF 3.2 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

International dental journal Pub Date : 2024-11-09 DOI:10.1016/j.identj.2024.10.003

Aaya Shahin, Yael Anne Leshem, Yossi Taieb, Sharon Baum, Aviv Barzilai, Danielle Jeddah, Efrat Sharon, Omry Koren, Rinat Tzach-Nahman, Shunit Coppenhagen-Glazer, Ronen Hazan, Yael Houri-Haddad, Shoshana Greenberger

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Abstract

Background: Systemic alterations in the oral cavity can be reflected in skin disorders like psoriasis. However, data about oral health factors that are affected and controlled mainly by oral microbiota in atopic dermatitis (AD) are sparse. This study compared the oral status and oral microbiota of AD patients and healthy controls.

Methods: This was a prospective sex- and age-matched case-control study comparing adult participants with and without dermatologist-verified AD. A dentist assessed oral health status, and oral flora samples were collected and subjected to 16S rRNA sequencing for microbiome analysis.

Results: Forty-five AD participants and 41 non-AD controls were recruited. Compared to the participants in the control group, those with AD had significantly higher plaque levels (P = .04), poorer oral hygiene indices (P = .04), and higher gingival index trends (P = .05). The oral microbiome in the AD group showed significantly higher diversity, both in α and β diversities (P = .001, P = .0007, respectively). Furthermore, AD patients had a significantly increased abundance of taxa correlated with oral diseases and a decreased abundance of bacteria associated with a healthy oral status.

Conclusion: AD appears to be associated with poor oral health and oral dysbiosis. There is a need to increase both patients' and physicians' awareness of oral health.

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成人特应性皮炎与口腔健康受损和口腔菌群失调的关系：病例对照研究

背景：口腔的系统性改变可反映在银屑病等皮肤疾病中。然而，有关特应性皮炎（AD）患者主要受口腔微生物群影响和控制的口腔健康因素的数据却很少。本研究比较了特应性皮炎患者和健康对照组的口腔状况和口腔微生物群：这是一项前瞻性的性别和年龄匹配病例对照研究，比较了经皮肤科医生证实患有特应性皮炎和未患有特应性皮炎的成年参与者。牙医评估口腔健康状况，收集口腔菌群样本并进行 16S rRNA 测序，以分析微生物组：结果：共招募了 45 名注意力缺失症患者和 41 名非注意力缺失症对照组患者。与对照组的参与者相比，AD 患者的牙菌斑水平明显更高（P = .04），口腔卫生指数更差（P = .04），牙龈指数趋势更高（P = .05）。AD 组的口腔微生物群在 α 和 β 多样性方面都显示出明显更高的多样性（分别为 P = .001 和 P = .0007）。此外，AD 患者与口腔疾病相关的类群数量明显增加，而与健康口腔状态相关的细菌数量则有所减少：结论：AD 似乎与口腔健康状况不佳和口腔菌群失调有关。有必要提高患者和医生对口腔健康的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International dental journal 医学-牙科与口腔外科

CiteScore

4.80

自引率

6.10%

发文量

159

审稿时长

63 days

期刊介绍： The International Dental Journal features peer-reviewed, scientific articles relevant to international oral health issues, as well as practical, informative articles aimed at clinicians.