Association Between Indices of Peripheral Blood Inflammation and Cavitary Pulmonary Tuberculosis.

IF 2.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
International Journal of General Medicine Pub Date : 2024-11-07 eCollection Date: 2024-01-01 DOI:10.2147/IJGM.S483185
Xiaoshan He, Hongbiao Hou, Yuting Jiang, Xiaohuan Huang
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引用次数: 0

Abstract

Objective: To explore inflammation markers of C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammatory index (SII), and systemic inflammatory response index (SIRI) in the differential diagnosis of cavitary pulmonary tuberculosis (PTB) from non-cavitary PTB.

Methods: This retrospective study included 1233 patients with PTB, 518 patients were diagnosed with cavitary PTB as case group, while 715 patients which diagnosed with non-cavitary PTB were selected as control group. The clinical data of patients was collected and the levels of inflammation indices were measured. Receiver operating characteristic (ROC) curve analysis was used to assess the diagnosis and analysis of selected indices. Logistic regression analysis was performed to evaluate the factors associated with cavitary PTB.

Results: The CRP, NLR, MLR, PLR, SII, and SIRI in the case group were significantly higher than those in the controls (all p<0.001). When cavitary PTB was taken as the endpoint, the optimal diagnostic thresholds of CRP was 35.365 (area under the ROC curve (AUC)=0.601), NLR was 5.740 (AUC=0.595), MLR was 0.525 (AUC=0.577), PLR was 198.255 (AUC=0.602), SII was 1252.045 (AUC=0.628), and SIRI was 2.095 (AUC=0.605), respectively. Logistic regression analysis showed that gender, CRP, PLR, and SIRI were the independent risk factors for cavitary PTB. The sensitivity of the combination of the three indices (CRP+PLR, CRP+SIRI, PLR+SIRI, and CRP+PLR+SIRI) were higher than those of the CRP, PLR, and SIRI.

Conclusion: CRP, PLR, and SIRI levels were associated with an increased likelihood of cavitary PTB. The combined detection of CRP, PLR, and SIRI is promising as a screening marker and may be useful for ruling out PTB with cavitary.

外周血炎症指数与腔隙性肺结核之间的关系
目的探讨C反应蛋白(CRP)、中性粒细胞与淋巴细胞比值(NLR)、单核细胞与淋巴细胞比值(MLR)、血小板与淋巴细胞比值(PLR)、全身免疫炎症指数(SII)和全身炎症反应指数(SIRI)等炎症指标在空洞型肺结核与非空洞型肺结核鉴别诊断中的作用:这项回顾性研究纳入了 1233 例肺结核患者,其中 518 例患者被诊断为空洞型肺结核,715 例患者被诊断为非空洞型肺结核。收集患者的临床数据并测量炎症指数水平。采用接收者操作特征曲线(ROC)分析来评估诊断和所选指标的分析。结果:病例组的 CRP、NLR、MLR、PLR、SII 和 SIRI 显著高于对照组(均为 p):CRP、PLR和SIRI水平与发生腔隙性肺结核的可能性增加有关。CRP、PLR和SIRI的联合检测有望作为筛查指标,并可用于排除腔隙性肺结核。
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来源期刊
International Journal of General Medicine
International Journal of General Medicine Medicine-General Medicine
自引率
0.00%
发文量
1113
审稿时长
16 weeks
期刊介绍: The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.
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