Immunoglobulin G4-related autoimmune hepatitis following type 1 autoimmune pancreatitis: A case report and literature review.

IF 1 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL
Chiharu Toh, Shinichi Morita, Nobutaka Takeda, Fusako Yamazaki, Kunihiko Yokoyama, Masatoshi Sato, Daisuke Kumaki, Takeshi Sakai, Kazuhiro Funakoshi, Koichi Tsuneyama
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引用次数: 0

Abstract

We herein report a case of IgG4-related autoimmune hepatitis (AIH) in a patient with a history of type 1 autoimmune pancreatitis. A 56-year-old man presented with fatigue and jaundice at our hospital. A blood biochemistry analysis revealed significant liver dysfunction, positive results for antinuclear antibodies, and high serum IgG4 levels. A histopathological examination revealed interface hepatitis marked by IgG4-positive plasma cell infiltration in the portal area, leading to liver cell depletion and necrosis. Based on the diagnosis of IgG4-related AIH, prednisolone treatment was initiated, which led to the rapid resolution of liver dysfunction and jaundice. An accurate diagnosis of IgG4-related AIH is crucial to prevent secondary manifestations.

1 型自身免疫性胰腺炎后出现免疫球蛋白 G4 相关自身免疫性肝炎:病例报告和文献综述。
我们在此报告一例 IgG4 相关自身免疫性肝炎(AIH)病例,患者曾患 1 型自身免疫性胰腺炎。一名 56 岁男子因乏力和黄疸到我院就诊。血液生化分析显示,患者肝功能明显异常,抗核抗体呈阳性,血清 IgG4 水平较高。组织病理学检查显示,门静脉区有 IgG4 阳性浆细胞浸润的界面性肝炎,导致肝细胞耗竭和坏死。根据 IgG4 相关性 AIH 的诊断,患者开始接受泼尼松龙治疗,肝功能异常和黄疸很快得到缓解。准确诊断 IgG4 相关性 AIH 对预防继发性表现至关重要。
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来源期刊
Internal Medicine
Internal Medicine 医学-医学:内科
CiteScore
1.90
自引率
8.30%
发文量
0
审稿时长
2.2 months
期刊介绍: Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.
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