The multifaceted anticancer potential of luteolin: involvement of NF-κB, AMPK/mTOR, PI3K/Akt, MAPK, and Wnt/β-catenin pathways.

IF 4.6 2区医学 Q2 IMMUNOLOGY

Inflammopharmacology Pub Date : 2024-11-14 DOI:10.1007/s10787-024-01596-8

Deepika Singh, Gaurav Shukla

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引用次数: 0

Abstract

Cancer is the predominant and major cause of fatality worldwide, based on the different types of cancer. There is a limitation in the current treatment. So we need better therapeutic agents that counteract the progression and development of malignant tumours. Plant-derived products are closely related and useful for human health. Luteolin is a polyphenolic flavonoid bioactive molecule that is present in various herbs, vegetables, fruits, and flowers and exhibits chemoprotective and pharmacological activity against different malignancies. To offer innovative approaches for the management of various cancers, we present a comprehensive analysis of the latest discoveries on luteolin. The aim is to inspire novel concepts for the development of advanced pharmaceuticals targeting cancer and search specifically targeted reviews and research articles published from January 1999 to January 2024 that investigated the application of luteolin in various cancer management. A thorough literature search utilizing the keywords "luteolin" "Signalling Pathway" "cancer" and nanoparticles was performed in the databases of Google Scholar, Web of Science, SCOPUS, UGC care list and PubMed. Through the compilation of existing research, we have discovered that luteolin possesses several therapeutic actions against various cancer via a signaling pathway involving the of NF-κB regulation, AMPK/mTOR, toll-like receptor, Nrf-2, PI3K/Akt MAPK and Wnt/β-catenin and their underlying mechanism of action has been well understood. This review intended to completely integrate crucial information on natural sources, biosynthesis, pharmacokinetics, signaling pathways, chemoprotective and therapeutic properties against various cancers, and nanoformulation of luteolin.

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木犀草素的多方面抗癌潜力：NF-κB、AMPK/mTOR、PI3K/Akt、MAPK 和 Wnt/β-catenin 通路的参与。

根据癌症的不同类型，癌症是导致全球死亡的主要原因。目前的治疗方法存在局限性。因此，我们需要更好的治疗药物来对抗恶性肿瘤的进展和发展。植物提取物与人类健康密切相关，对人类健康非常有用。木犀草素是一种多酚类黄酮生物活性分子，存在于各种草药、蔬菜、水果和花卉中，对不同的恶性肿瘤具有化学保护和药理活性。为了提供治疗各种癌症的创新方法，我们对最新发现的木犀草素进行了全面分析。我们的目的是启发开发针对癌症的先进药物的新概念，并专门针对 1999 年 1 月至 2024 年 1 月期间发表的、研究叶黄素在各种癌症治疗中的应用的评论和研究文章进行搜索。利用关键词 "木犀草素""信号通路""癌症 "和纳米粒子，在谷歌学术、科学网、SCOPUS、UGC care list 和 PubMed 等数据库中进行了全面的文献检索。通过对现有研究的梳理，我们发现叶黄素通过涉及 NF-κB 调节、AMPK/mTOR、类收费受体、Nrf-2、PI3K/Akt MAPK 和 Wnt/β-catenin 的信号通路对各种癌症具有多种治疗作用，其潜在的作用机制已被充分了解。本综述旨在全面整合有关木犀草素的天然来源、生物合成、药代动力学、信号传导途径、化学保护和对各种癌症的治疗特性以及纳米制剂等方面的重要信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Inflammopharmacology IMMUNOLOGYTOXICOLOGY-TOXICOLOGY

CiteScore

8.00

自引率

3.40%

发文量

200

期刊介绍： Inflammopharmacology is the official publication of the Gastrointestinal Section of the International Union of Basic and Clinical Pharmacology (IUPHAR) and the Hungarian Experimental and Clinical Pharmacology Society (HECPS). Inflammopharmacology publishes papers on all aspects of inflammation and its pharmacological control emphasizing comparisons of (a) different inflammatory states, and (b) the actions, therapeutic efficacy and safety of drugs employed in the treatment of inflammatory conditions. The comparative aspects of the types of inflammatory conditions include gastrointestinal disease (e.g. ulcerative colitis, Crohn''s disease), parasitic diseases, toxicological manifestations of the effects of drugs and environmental agents, arthritic conditions, and inflammatory effects of injury or aging on skeletal muscle. The journal has seven main interest areas: -Drug-Disease Interactions - Conditional Pharmacology - i.e. where the condition (disease or stress state) influences the therapeutic response and side (adverse) effects from anti-inflammatory drugs. Mechanisms of drug-disease and drug disease interactions and the role of different stress states -Rheumatology - particular emphasis on methods of measurement of clinical response effects of new agents, adverse effects from anti-rheumatic drugs -Gastroenterology - with particular emphasis on animal and human models, mechanisms of mucosal inflammation and ulceration and effects of novel and established anti-ulcer, anti-inflammatory agents, or antiparasitic agents -Neuro-Inflammation and Pain - model systems, pharmacology of new analgesic agents and mechanisms of neuro-inflammation and pain -Novel drugs, natural products and nutraceuticals - and their effects on inflammatory processes, especially where there are indications of novel modes action compared with conventional drugs e.g. NSAIDs -Muscle-immune interactions during inflammation [...]