Burden of post-acute COVID-19 sequelae in healthcare workers and its course over a 30-month period-results from a prospective multicentre cohort.

IF 5.4 2区医学 Q1 INFECTIOUS DISEASES

Infection Pub Date : 2024-11-12 DOI:10.1007/s15010-024-02418-3

Tamara Dörr, Carol Strahm, Sabine Güsewell, Tala Ballouz, Emina Kocan, Alexia Cusini, Stephan Goppel, Fabian Grässli, J Carsten Möller, Milo A Puhan, Lorenz Risch, Markus Ruetti, Matthias Schlegel, Reto Stocker, Matthias von Kietzell, Danielle Vuichard-Gysin, Stefan P Kuster, Christian R Kahlert, Philipp Kohler

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引用次数: 0

Abstract

Purpose: As healthcare workers (HCW) have been disproportionally affected by COVID-19, its post-acute sequelae (PASC) in HCW can impact healthcare systems. We assessed the burden and course of PASC in HCW over a 30-month period.

Methods: In a prospective multicentre HCW cohort in Switzerland, PASC surveys were conducted in 03/2021, 09/2021, 06/2022, 04/2023, and 10/2023. Stratified by viral variant at first infection, the prevalence of PASC symptoms, self-experienced PASC and the Post-COVID Functional Status (PCFS) were analysed cross-sectionally in 10/2023, self-perceived success of therapeutic measures used was assessed. The evolution of PASC symptoms and PCFS in Wild-type and non-Wild-type infected HCW compared to uninfected controls was analysed longitudinally across all surveys.

Results: In cross-sectional analysis, 1704 HCW (median age 47 years, 82.2% female) were included. Thereof, 30.7% reported ≥ 1 PASC symptom in 10/2023, with 115 (6.7%) stating to have or have had PASC. Both were most common after Wild-type infection compared to other variants. Overall, 17/115 (15%) indicated relevant/severe restrictions in their daily activities and of 85 (74%) that tried ≥ 1 measure against their symptoms, 69 (81%) reported having benefitted. Longitudinal analysis (n = 653) showed a significantly higher proportion of Wild-type infected HCW to report PASC symptoms compared to controls in 03/2021 (+ 21%, 95% CI 4-39), with decreasing trend (+ 7%, 95%CI -10-25 in 10/2023). This effect was not evident for non-Wild-type infected HCW.

Conclusions: Over a 30 month period, overall PASC burden in our HCW cohort decreased, although 1% still experience relevant restrictions in their daily life; Wild-type infected individuals show the highest disease burden.

查看原文本刊更多论文

医护人员急性 COVID-19 后遗症的负担及其 30 个月的病程--一项前瞻性多中心队列研究的结果。

目的：由于医护人员（HCW）受到 COVID-19 的影响尤为严重，因此医护人员的急性后遗症（PASC）会对医疗系统造成影响。我们评估了 30 个月内医护人员 PASC 的负担和病程：在瑞士的一个前瞻性多中心高危人群队列中，分别于 2021 年 3 月、2021 年 9 月、2022 年 6 月、2023 年 4 月和 2023 年 10 月进行了 PASC 调查。根据首次感染时的病毒变体进行分层，在 2023 年 10 月对 PASC 症状的流行率、自我体验的 PASC 和后 COVID 功能状态（PCFS）进行了横断面分析，并对所使用治疗措施的自我成功感进行了评估。与未感染的对照组相比，纵向分析了野生型和非野生型感染的高危人群的 PASC 症状和 PCFS 在所有调查中的演变情况：在横断面分析中，共纳入了 1704 名高危工人（中位年龄为 47 岁，82.2% 为女性）。其中，30.7%的人在10/2023中报告了≥1种PASC症状，115人（6.7%）表示患有或曾经患有PASC。与其他变种相比，野生型感染后这两种症状最为常见。总体而言，17/115（15%）人表示其日常活动受到相关/严重限制，85（74%）人尝试了≥1种针对其症状的措施，其中 69（81%）人表示已从中受益。纵向分析（n = 653）显示，与对照组相比，野生型感染的高危工人报告 PASC 症状的比例在 2021 年 3 月显著增加（+ 21%，95% CI 4-39），并呈下降趋势（2023 年 10 月 + 7%，95% CI -10-25）。这种效应在非威尔特型感染的高危女工中并不明显：在 30 个月的时间里，我们的高危人群总体 PASC 负担有所减轻，但仍有 1%的人在日常生活中受到相关限制；野生型感染者的疾病负担最高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infection 医学-传染病学

CiteScore

12.50

自引率

1.30%

发文量

224

审稿时长

6-12 weeks

期刊介绍： Infection is a journal dedicated to serving as a global forum for the presentation and discussion of clinically relevant information on infectious diseases. Its primary goal is to engage readers and contributors from various regions around the world in the exchange of knowledge about the etiology, pathogenesis, diagnosis, and treatment of infectious diseases, both in outpatient and inpatient settings. The journal covers a wide range of topics, including: Etiology: The study of the causes of infectious diseases. Pathogenesis: The process by which an infectious agent causes disease. Diagnosis: The methods and techniques used to identify infectious diseases. Treatment: The medical interventions and strategies employed to treat infectious diseases. Public Health: Issues of local, regional, or international significance related to infectious diseases, including prevention, control, and management strategies. Hospital Epidemiology: The study of the spread of infectious diseases within healthcare settings and the measures to prevent nosocomial infections. In addition to these, Infection also includes a specialized "Images" section, which focuses on high-quality visual content, such as images, photographs, and microscopic slides, accompanied by brief abstracts. This section is designed to highlight the clinical and diagnostic value of visual aids in the field of infectious diseases, as many conditions present with characteristic clinical signs that can be diagnosed through inspection, and imaging and microscopy are crucial for accurate diagnosis. The journal's comprehensive approach ensures that it remains a valuable resource for healthcare professionals and researchers in the field of infectious diseases.